Advertisement

Iontophoresis as a new method of delivering local anesthesia to the urethra: a pilot study

  • Emma Gorton
    Correspondence
    Reprint requests: Emma Gorton, Department of Obstetrics and Gynaecology, St. Georges Hospital, Blackshaw Road, Tooting, London SW17 0QT, United Kingdom
    Affiliations
    Department of Obstetrics and Gynaecology, St. George’s Hospital, Tooting, London, United Kingdom
    Search for articles by this author
  • Stuart Stanton
    Affiliations
    Department of Obstetrics and Gynaecology, St. George’s Hospital, Tooting, London, United Kingdom
    Search for articles by this author

      Abstract

      Objectives. To test the feasibility of using the iontophoretic catheter as a means of delivering local anesthetic (lidocaine hydrochloride) to the urethra for periurethral injection of collagen.
      Methods. Eight women with urodynamically proven genuine stress incontinence underwent periurethral collagen injections. Local anesthesia was provided by 4% lidocaine with 1 in 100,000 epinephrine administered over 10 minutes using an iontophoretic catheter. Pain was assessed by Likert and visual analogue scales. Cystoscopic appearance of the urethra was noted.
      Results. The periurethral bulking procedure was completed without further anesthetic in 7 women, 1 of whom had no pain. There was no evidence of urethral damage from the iontophoresis.
      Conclusions. Iontophoresis shows promise as a method of providing analgesia to the urethra. However, the degree of analgesia is variable, and further research is needed on catheter design to ensure transport of anesthetic agent into the periurethral tissues.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Urology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Iresfeld S
        • Klement W
        • Lipert P
        Dermal anaesthesia.
        Br J Anaesth. 1993; 71: 375-378
        • Monga A.K
        • Robinson D
        • Stanton S.L
        Periurethral collagen injections for genuine stress incontinence.
        Br J Urol. 1995; 76: 156-160
        • Núñez M
        • Miralles E.S
        • Boixeda P
        • et al.
        Iontophoresis for anesthesia during pulsed dye laser treatment of port-wine stains.
        Pediatr Dermatol. 1997; 14: 397-400
        • Roberts M.S
        Targeted drug delivery to the skin and deeper tissues.
        Clin Exp Pharmacol Physiol. 1997; 24: 874-879
        • Png D.J
        • Li M.K
        Use of iontophoretic anaesthesia in urologic surgery.
        Singapore Med J. 1996; 37: 636-638