Abstract
Objectives. To test the feasibility of using the iontophoretic catheter as a means
of delivering local anesthetic (lidocaine hydrochloride) to the urethra for periurethral
injection of collagen.
Methods. Eight women with urodynamically proven genuine stress incontinence underwent
periurethral collagen injections. Local anesthesia was provided by 4% lidocaine with
1 in 100,000 epinephrine administered over 10 minutes using an iontophoretic catheter.
Pain was assessed by Likert and visual analogue scales. Cystoscopic appearance of
the urethra was noted.
Results. The periurethral bulking procedure was completed without further anesthetic
in 7 women, 1 of whom had no pain. There was no evidence of urethral damage from the
iontophoresis.
Conclusions. Iontophoresis shows promise as a method of providing analgesia to the
urethra. However, the degree of analgesia is variable, and further research is needed
on catheter design to ensure transport of anesthetic agent into the periurethral tissues.
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References
- Dermal anaesthesia.Br J Anaesth. 1993; 71: 375-378
- Periurethral collagen injections for genuine stress incontinence.Br J Urol. 1995; 76: 156-160
- Iontophoresis for anesthesia during pulsed dye laser treatment of port-wine stains.Pediatr Dermatol. 1997; 14: 397-400
- Targeted drug delivery to the skin and deeper tissues.Clin Exp Pharmacol Physiol. 1997; 24: 874-879
- Use of iontophoretic anaesthesia in urologic surgery.Singapore Med J. 1996; 37: 636-638
Article info
Publication history
Accepted:
October 20,
1998
Received in revised form:
October 20,
1998
Received:
August 24,
1998
Identification
Copyright
© 1999 Elsevier Science Inc. Published by Elsevier Inc. All rights reserved.
