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Abstract
Objectives
To determine whether men with chronic prostatitis/chronic pelvic pain syndrome have
evidence of an autoimmune response to prostatic proteins. We examined men with a history
of chronic prostatitis/ chronic pelvic pain syndrome for evidence of T lymphocyte
reactivity to seminal plasma.
Methods
Patients underwent automated leukopheresis to obtain peripheral blood mononuclear
cells. We performed a recall antigen proliferation assay to detect specific proliferation
of peripheral helper T lymphocytes in men with chronic prostatitis/chronic pelvic
pain syndrome and compared the results with those of normal men. The antigen for these
studies consisted of seminal plasma from normal donors and men with seminal vesicle
atresia.
Results
A specific recall proliferative response to seminal plasma was observed in 3 of 10
men with a history of chronic prostatitis/chronic pelvic pain syndrome compared with
none of 15 normal men. The CD4 T cell proliferative response to seminal plasma was
statistically significant when compared with medium alone in men with a history of
chronic prostatitis/chronic pelvic pain syndrome but it was not statistically significant
in normal men. The recall responses of both the chronic prostatitis/chronic pelvic
pain syndrome group and normal subjects to the recall antigens tetanus toxoid and
Candida extract were equivalent.
Conclusions
The data represent the first direct evidence that some men with chronic prostatitis/chronic
pelvic pain syndrome have an autoimmune component to their disease. Autoimmunity is
a potential etiology for chronic nonbacterial prostatitis.
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Article info
Publication history
Accepted:
June 27,
1997
Received:
April 1,
1997
Footnotes
**Supported by a grant from the U.S. Department of Veterans Affairs.
Identification
Copyright
© 1997 Elsevier Science Inc. all rights reserved. Published by Elsevier Inc.
