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Abstract
Objectives
To determine whether men with chronic prostatitis/chronic pelvic pain syndrome have
evidence of an autoimmune response to prostatic proteins. We examined men with a history
of chronic prostatitis/ chronic pelvic pain syndrome for evidence of T lymphocyte
reactivity to seminal plasma.
Methods
Patients underwent automated leukopheresis to obtain peripheral blood mononuclear
cells. We performed a recall antigen proliferation assay to detect specific proliferation
of peripheral helper T lymphocytes in men with chronic prostatitis/chronic pelvic
pain syndrome and compared the results with those of normal men. The antigen for these
studies consisted of seminal plasma from normal donors and men with seminal vesicle
atresia.
Results
A specific recall proliferative response to seminal plasma was observed in 3 of 10
men with a history of chronic prostatitis/chronic pelvic pain syndrome compared with
none of 15 normal men. The CD4 T cell proliferative response to seminal plasma was
statistically significant when compared with medium alone in men with a history of
chronic prostatitis/chronic pelvic pain syndrome but it was not statistically significant
in normal men. The recall responses of both the chronic prostatitis/chronic pelvic
pain syndrome group and normal subjects to the recall antigens tetanus toxoid and
Candida extract were equivalent.
Conclusions
The data represent the first direct evidence that some men with chronic prostatitis/chronic
pelvic pain syndrome have an autoimmune component to their disease. Autoimmunity is
a potential etiology for chronic nonbacterial prostatitis.
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References
- Chronic prostatitis: results of an Internet survey.Urology. 1996; 48: 568-574
- Chronic prostatistis: a thorough search for etiologically involved microorganisms in 1,461 patients.Infection. 1991; 19: S119-S125
- Diagnosis and treatment of 409 patients with prostatitis syndromes.Urology. 1993; 41: 301-307
- Comprehensive evaluation and treatment of 75 men referred to chronic prostatitis clinic.Urology. 1991; 38: 11-19
- Diagnostic considerations and interpretation of microbiological findings for evaluation of chronic prostatitis.J Clin Microbiol. 1989; 27: 2240-2244
- Transurethral microwave thermotherapy for nonbacterial prostatitis: a randomized double-blind sham controlled study using new prostatitis specific assessment questionnaires.J Urol. 1996; 155: 1950-1954
- Chronic pelvic pains represent the most prominent urogenital symptoms of chronic prostatitis.Urology. 1996; 48: 715-721
- Bacteriologic localization patterns in bacterial prostatitis and urethritis.Invest Urol. 1968; 5: 492-518
- Classification of benign diseases associated with prostatic pain: prostatitis or prostatodynia?.J Urol. 1978; 120: 266
- Prostatitis and related disorders.in: Walsh PC Retik AB Stamey TA Vaughan ED Campbell's Urology. WB Saunders, Philadelphia1996: 807-822
- Prevalence and significance of prostatic inflammation.J Urol. 1981; 125: 215-219
- Case-control study of men with suspected chronic idiopathic prostatitis.J Urol. 1989; 141: 328-331
- Search for uro-genital tract infections in patients with symptoms of prostatitis. Studies on aerobic and strictly anaerobic bacteria, mycoplasmas, fungi, trichomonads and viruses.Scand J Urol Nephrol. 1975; 9: 8-16
- Chlamydia trachomatis in chronic abacterial prostatitis: demonstration by colorimetric in situ hybridization.Hum Pathol. 1991; 22: 41-44
- Role of Chlamydia trachomatis and mycoplasmas in chronic prostatitis. A review.Urol Int. 1988; 43: 167-173
- The characterization of nonbacterial prostatitis: search for an etiology.J Urol. 1992; 148: 1461-1466
- Bacterial prostatitis vs “prostatosis.” A clinical and bacteriological study.JAMA. 1973; 224: 1372-1375
- Prokaryotic DNA sequences in patients with chronic idiopathic prostatitis.J Clin Microbiol. 1996; 34: 3120-3128
- Bacteria in the prostate tissue of men with idiopathic prostatic inflammation.J Urol. 1997; 157: 863-865
- Patterns of inflammation in prostatic hyperplasia: a histologic and bacteriologic study.J Urol. 1979; 121: 755-760
- Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia.Lab Invest. 1992; 66: 96-107
- Phenotype and function of peripheral and prostatic lymphocytes in patients with benign prostatic hyperplasia.J Urol. 1994; 151: 480-484
- Autoantibodies to prostate specific antigen in patients with benign prostatic hyperplasia.J Urol. 1995; 154: 1052-1055
- The role of Chlamydia trachomatis in chronic abacterial prostatics: a study using ultrasound guided biopsy.J Urol. 1989; 141: 332-333
Article Info
Publication History
Accepted:
June 27,
1997
Received:
April 1,
1997
Footnotes
**Supported by a grant from the U.S. Department of Veterans Affairs.
Identification
Copyright
© 1997 Elsevier Science Inc. all rights reserved. Published by Elsevier Inc.
