Objective
To determine how the LURN-SI-10, a novel questionnaire developed by the Symptoms of
Lower Urinary Tract Dysfunction Research Network (LURN), compares with the International
Prostate Symptom Score (IPSS) in men with lower urinary tract symptoms (LUTS) attributed
to benign prostatic hyperplasia (BPH). Specifically, to assess convergent validity
and determine how frequently the LURN-SI-10 identifies symptoms not captured by the
IPSS.
Materials and Methods
Men presenting with BPH/LUTS were prospectively administered LURN-SI-10 and IPSS questionnaires.
Urinary incontinence (UI) including post-void dribbling (PVD), urgency urinary incontinence
(UUI), stress urinary incontinence (SUI), as well as bladder pain were considered
present if the patient reported “about half the time or more” on LURN-SI-10. Correlations
between LURN-SI-10 and IPSS were assessed as continuous and categorical variables.
Multivariable linear regression analysis was performed to determine associations with
symptom scores.
Results
LURN-SI-10 and IPSS were highly correlated in men with BPH/LUTS (r = 0.82, n = 429),
as were respective bother and quality of life scores (ρ = 0.74). The LURN-SI-10 identified
additional symptoms including PVD (24%), UUI (13%), SUI (2%), and pain (8%). Men with
any UUI, SUI, or PVD had on average a 7.6-point higher LURN-SI-10 score than those
without UI (P<.001) and 8.0-point higher IPSS score than those without UI (P<.001).
Conclusion
The LURN-SI-10 correlates strongly with the IPSS, but the LURN-SI-10 identifies additional
important symptomatology in men with LUTS. This additional information may improve
the evaluation and treatment of men with BPH/LUTS. Further prospective studies of
the LURN-SI-10 is warranted.
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Article info
Publication history
Published online: November 09, 2022
Accepted:
October 24,
2022
Received:
July 25,
2022
Footnotes
Financial Disclosure: The authors declare that they have no relevant financial interests.
This study was presented in part at AUA 2021 (MP28-04; https://doi.org/10.1097/JU.0000000000002025.04). The LURN SI-10 and LURN-SI-29 questionnaires, user manuals, and further information about development of these questionnaires as part of LURN are publicly available at: https://nih-lurn.org/Resources/Questionnaires.Funding Statement: This study received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
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