Abstract
Objective
To examine the association between chronic spontaneous urticaria (CSU) and interstitial
cystitis/bladder pain syndrome (IC/BPS).
Methods
A population-based retrospective cross-sectional study was performed using the Clalit
Health Services medical database. The prevalence of CSU was compared between patients
diagnosed with IC/BPS and age- and gender-matched controls. Univariate analysis was
performed using Chi-square and Student t test and a multivariable analysis was performed using a logistic regression model.
Results
The study included 681 patients with IC/BPS and 3376 demographically matched controls.
The mean age of IC/BPS patients was 60 years old. The prevalence of CSU among patients
with IC/BPS was higher as compared to the control group (20% vs 13.7%; P <.001). The adjusted OR for CSU in patients with IC/BPS was 1.58 (95% CI 1.28-1.97).
Female gender and Jewish ethnicity were associated with the coexistence of these disorders
(OR 1.7 95% CI 1.36-2.13, and 1.6 95% CI 1.28-2, respectively).
Conclusion
A significant association was found between IC/BPS and CSU. This finding may support
the presence of allergic/immune components in the pathogenesis of IC/BPS.
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Article info
Publication history
Published online: November 04, 2022
Accepted:
October 23,
2022
Received:
June 22,
2022
Footnotes
Financial Disclosure: None related to this manuscript. Tali Czarnowicki served as a consultant, advisor, or speaker to Abbvie; Novartis; Sanofi Arnon Cohen served as a consultant, advisor, or speaker to Abbvie; Amgen; Boehringer Ingelheim; Dexcel pharma; Janssen; Kamedis; Lilly; Neopharm; Novartis; Perrigo; Pfizer, Rafa, Sanofi, Sirbal; Taro.
The rest of the authors have declared no conflict of interests.
Funding Support: None.
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