Chronic Spontaneous Urticaria in Patients With Interstitial Cystitis/Bladder Pain Syndrome: Insights From Big Data Analyses

  • Author Footnotes
    # Equal contribution
    Omer Anis
    # Equal contribution
    Urology department, Sheba Medical Center, Ramat Gan, Israel

    The Mina & Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel

    Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
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  • Author Footnotes
    # Equal contribution
    Khalaf Kridin
    # Equal contribution
    Unit of Dermatology and Skin Research Laboratory, Baruch Padeh Medical Center, Poriya, Tiberias, Israel

    Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

    Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany
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  • Arnon Dov Cohen
    Department of Quality Measures and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel

    Siaal Research Center for Family Medicine and Primary care, The Haim Doron Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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  • Miriam Levmore
    Community Medical Services Division, Clalit Health Services, Tel Aviv, Israel
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  • Shlomit Yaron
    Community Medical Services Division, Clalit Health Services, Tel Aviv, Israel
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  • Yuliya Valdman-Grinshpoun
    Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel
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  • Tali Czarnowicki
    Address correspondence to: Tali Czarnowicki, M.D. M.Sc, Dermatology, Shaare Zedek Medical Center, Shmu'el Bait St 12, Jerusalem, 9103102, Israel.
    Shaare Zedek Medical Center, the Hebrew University of Jerusalem, Jerusalem, Israel

    Department of Dermatology and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY
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  • Author Footnotes
    # Equal contribution
Published:November 04, 2022DOI:



      To examine the association between chronic spontaneous urticaria (CSU) and interstitial cystitis/bladder pain syndrome (IC/BPS).


      A population-based retrospective cross-sectional study was performed using the Clalit Health Services medical database. The prevalence of CSU was compared between patients diagnosed with IC/BPS and age- and gender-matched controls. Univariate analysis was performed using Chi-square and Student t test and a multivariable analysis was performed using a logistic regression model.


      The study included 681 patients with IC/BPS and 3376 demographically matched controls. The mean age of IC/BPS patients was 60 years old. The prevalence of CSU among patients with IC/BPS was higher as compared to the control group (20% vs 13.7%; P <.001). The adjusted OR for CSU in patients with IC/BPS was 1.58 (95% CI 1.28-1.97). Female gender and Jewish ethnicity were associated with the coexistence of these disorders (OR 1.7 95% CI 1.36-2.13, and 1.6 95% CI 1.28-2, respectively).


      A significant association was found between IC/BPS and CSU. This finding may support the presence of allergic/immune components in the pathogenesis of IC/BPS.
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