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Multifocal Paraganglioma in Teenager Presenting With Hypertension

Published:October 21, 2022DOI:https://doi.org/10.1016/j.urology.2022.10.006

      Abstract

      Pediatric hypertension represents a rare though increasingly common medical problem. When encountered, a workup to determine the etiology should be conducted. In this report, we detail an unusual case in which a teenager presenting with hypertension was found to have multifocal primary paragangliomas. We illustrate important considerations in management which include appropriate preoperative labs and imaging, collaboration with endocrinology for preoperative alpha-blockade, surgical management with close perioperative hemodynamic control, and genetic evaluation for all patients with paragangliomas.
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      References

        • Havekes B
        • Romijn JA
        • Eisenhofer G
        • Adams K
        • Pacak K.
        Update on pediatric pheochromocytoma.
        Pediatr Nephrol. 2009; 24: 943-950
        • Bholah R
        • Bunchman TE.
        Review of pediatric pheochromocytoma and paraganglioma.
        Front Pediatr. 2017; 5: 155
        • Bausch B
        • Wellner U
        • Bausch D
        • et al.
        Long-term prognosis of patients with pediatric pheochromocytoma.
        Endocr Relat Cancer. 2014; 21: 17-25
        • Fishbein L.
        Pheochromocytoma and paraganglioma: Genetics, diagnosis, and treatment.
        Hematol Oncol Clin North Am. 2016; 30: 135-150
        • Bardella C
        • Pollard PJ
        • Tomlinson I.
        SDH mutations in cancer.
        Biochim Biophys Acta. 2011; 1807: 1432-1443
        • Andrews KA
        • Ascher DB
        • Pires DEV
        • et al.
        Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD.
        J Med Genet. 2018; 55: 384-394
        • Ricketts CJ
        • Forman JR
        • Rattenberry E
        • et al.
        Tumor risks and genotype-phenotype-proteotype analysis in 358 patients with germline mutations in SDHB and SDHD.
        Hum Mutat. 2010; 31: 41-51
        • Else T
        • Greenberg S
        • Fishbein L
        • et al.
        Hereditary paraganglioma-pheochromocytoma syndromes.
        in: Adam MP ED Mirzaa GM GeneReviews® [Internet]. University of Washington, Seattle, Washington2008 ([Updated 2018 Oct 4])

      Further Reading

        • Welander J
        • Söderkvist P
        • Gimm O.
        Genetics and clinical characteristics of hereditary pheochromocytomas and paragangliomas.
        Endocr Relat Cancer. 2011; 18: R253-R276