Abstract
OBJECTIVE
To critically evaluate time dependent sexual function following primary partial gland
cryo-ablation (PGCA) stratified according to baseline erectile function.
METHODS
Between March 2017 and March 2022, all men undergoing primary PGCA by 2 surgeons were
enrolled in an IRB approved outcomes registry. All subjects with PIRADS 2-5 lesion
concordant with unilateral GGG 1-3 disease, no gross extra-prostatic extension on
mpMRI, GGG >1 contralateral to the ROI, or distal apical disease on mpMRI were enrolled.
Patients completed the Sexual Health Inventory for Men (SHIM) scale at baseline, 6,
and 24 months. Men were stratified by baseline erectile function. Men with SHIM Score
< 8 were excluded. Ability to sustain erection (aka “potency”) was defined as a score
of 3 or greater on question 2 of the SHIM index. Median SHIM scores and the proportion
of men reporting “potency” at baseline, 6, and 24 months was recorded with comparisons
between each timepoint. A univariate analysis was used to determine if clinical factors
were associated with loss of “potency” at 24 months.
RESULTS
106 men met the inclusion criteria. There was a statistically significant decrease
in the mean SHIM scores for the entire cohort between baseline to 6 months and baseline
to 24 months. SHIM scores increased significantly for the total cohort between 6 and
24 months. “Potency” was preserved in 70% at 24 months.
CONCLUSION
Those patients most likely to exhibit a decrease in sexual function have moderate
ED at baseline. Only baseline ED was shown to predict preservation of “potency”.
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Article info
Publication history
Published online: October 19, 2022
Accepted:
October 4,
2022
Received:
August 17,
2022
Footnotes
James Wysock and Sameer Thakker contributed equally.
Financial Disclosure: The authors declare that they have no relevant financial interests.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
