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Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaNephropathy Clinical Medical Research Center of Sichuan Province, China
Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaNephropathy Clinical Medical Research Center of Sichuan Province, China
Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaNephropathy Clinical Medical Research Center of Sichuan Province, China
Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaNephropathy Clinical Medical Research Center of Sichuan Province, China
Address correspondence to: Rui Jiang, Ph.D., M.D., Department of Urology, Nephropathy Clinical Medical Research Center of Sichuan Province, Affiliated Hospital, Southwest medical University, Taiping Road, Luzhou, Sichuan 646000, China.
Affiliations
Department of Urology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaNephropathy Clinical Medical Research Center of Sichuan Province, China
A 64-year-old man with hypertension (156/76 mm Hg) without associated tachycardia
was admitted to our hospital for a 1-week history of left-sided loin pain. Routine
blood work indicated that hemoglobin was 10.3 g/dL and the ratio of neutrophil-to-lymphocyte
(NLR) was 4.9. Complete metabolic panel and serum catecholamines were normal. Computed
tomography (CT) revealed a round soft tissue mass measuring 55 × 45 × 35 mm located
beside the left renal hilum and 10 mm away from the celiac trunk. 2 renal hilum lymph
nodes were visible. The lesions showed enhancement in contrast-enhanced CT (52 Hounsfield
unit) compared to that in plain CT (37 Hounsfield unit) (Fig. 1). The patient was treated by laparoscopic radical resection of lesion. The mass was
a gray-white cut surface (Fig. 2). Histologically, the tumor cells were cuboidal and arranged in irregular tubular
or glandular formations. Immunohistochemical staining showed positive expression of
CK7, CK8, CK19, 34BE12, Vimentin, Pax8, and Integrase Interactor 1 (INI-1), and negative
expression of CK20, P63, GATA3, CD117, P504S, S100P, Pax2 and OCT3/4. Two lymph nodes
were positive for malignant cells (Fig. 3). The patient's left-sided loin pain was relieved, and the postoperative blood pressure
had no significant change compared with the preoperative one after 3 month of follow-up.
Figure 1(A) Abdominal CT showed a round soft tissue mass with a maximum diameter of 55mm located
besidethe left side of the abdominal aorta. The enhanced scan showed mild-to-moderate
heterogeneous enhancement (white arrows). (B) Both kidneys were morphologically intact.
The mass was located outside the kidney (white arrows). 2 lymph nodes were visible
around the renal hilum (red arrows). (C) The upper pole of the mass was adjacent to
the left renal artery (white arrows).
Figure 2The mass was about 6.0 × 4.8 × 3.7cm lobulated solid tumor, with a gray-white cut
surface. Focal hemorrhage and necrosis in the mass were visible.
Kunju LP. p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system.
Prospective multicenter phase II study of gemcitabine plus platinum salt for metastatic collecting duct carcinoma: results of a GETUG (Groupe d'Etudes des Tumeurs Uro-Génitales) study.
Financial Disclosure:This study was supported by the Research Foundation of the Department of Human Resources and Social Security of Sichuan Province of Returned Scholars grant 2019-76.
