Abstract
Objective
To elucidate the association between adolescent microscopic hematuria and early onset
urothelial carcinoma and renal cell carcinoma.
Methods
Nationwide, population-based, retrospective cohort study using medical data of 970,366
adolescents aged 16 through 19 years (58.6% male) examined for fitness for military
service between 1980 and 1997. Diagnoses of persistent isolated microscopic hematuria
were given after thorough work up process excluding any other renal abnormalities.
Incident cases of urothelial carcinoma and renal cell carcinoma diagnosed during the
years of 1982-2012 were retrieved from the Israeli National Cancer Registry. Cox proportional
hazards models were used to estimate the hazard ratio (HR) separately for urothelial
carcinoma and renal cell carcinoma.
Results
During a cumulative follow-up of 22,115,629 person-years (median follow-up, 22.8),
persistent isolated microscopic hematuria was diagnosed among 5509 (0.6%) adolescents.
Urothelial carcinoma and renal cell carcinoma developed in 332 (3 among those with
persistent isolated microscopic hematuria) and 292 (2) individuals, respectively.
The adjusted HR for incident urothelial carcinoma among adolescents with isolated
microscopic hematuria was 1.17 (95% CI, 0.38-3.66) and the adjusted HR for renal cell
carcinoma was 1.02 (95% CI, 0.25-4.12).
Conclusion
Persistent asymptomatic isolated microscopic hematuria at adolescence was not associated
with increased risk for urothelial carcinoma nor renal cell carcinoma.
Abbreviations:
ESRD (end stage renal disease), RCC (renal cell carcinoma), IDF (Israeli defense forces), INCR (Israeli National Cancer Registry), BMI (body mass index), CT (computed tomography)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: August 16, 2022
Accepted:
June 26,
2022
Received:
February 12,
2022
Footnotes
Financial Disclosure: The authors have no conflict of interests to report.
Funding Support: No funding sources. No author has been paid to write this article by a pharmaceutical company or any other agency.
Ethical approval:The study was approved by the IDF's ethics committee, who waived the requirement for informed consent since data were obtained from medical records without the participation of patients. Number of approval 1458201413.
Prior presentation: An abstract of the preliminary results was presented in the ERA-EDTA conference 2020 https://www.era-edta.org/VirtualCongress2020/Accepted_Abstracts_ERAEDTA_2020.pdf
Identification
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