Abstract
Over the past few decades, there have been significant advances in male infertility,
particularly in the development of novel diagnostic tools. Unfortunately, there remains
a substantial number of patients that remain infertile despite these improvements.
In this review, we take heed of the emerging technologies that will shape the future
of male infertility diagnosis, evaluation, and treatment. Improvement in computer-assisted
semen analyses and portability allow males to obtain basic semen parameters from the
comfort of their home. Additionally, breakthrough ultrasound technology allows for
preoperative prediction of potential areas of spermatogenesis within the testes, high-resolution
optics permits better visualization during microdissection testicular sperm extraction
(mTESE), and artificial intelligence improves sperm selection and identification.
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References
- Fertility and infertility: definition and epidemiology.Clin Biochem. 2018; 62: 2-10
- Technological advancements in male infertility microsurgery.J Clin Med. 2021; 10: 2-3
- Current medical management of endocrine-related male infertility.Asian J Androl. 2016; 18: 357-363
- Gonadotrophins for idiopathic male factor subfertility.Cochrane Database Syst Rev. 2013; CD005071
- Uncertainty of measurement and clinical value of semen analysis: has standardisation through professional guidelines helped or hindered progress?.Andrology. 2016; 4: 763-770
- The validity and reliability of computer-aided semen analyzers in performing semen analysis: a systematic review.Transl Androl Urol. 2021; 10: 3069-3079
- Validation of LensHooke(R) X1 PRO and computer-assisted semen analyzer compared with laboratory-based manual semen analysis.World J Mens Health. 2021; 39: 496-505
- Standardized laboratory procedures, quality control and quality assurance are key requirements for accurate semen analysis in the evaluation of infertile male.World J Mens Health. 2022; 40: 52-65
- The future of computer-aided sperm analysis.Asian J Androl. 2015; 17: 545-553
- Comparison of semen parameters in samples collected by masturbation at a clinic and at home.Fertil Steril. 2008; 89: 1718-1722
- Emerging technologies for home-based semen analysis.Andrology. 2018; 6: 10-19
- Clinical update on home testing for male fertility.World J Mens Health. 2021; 39: 615-625
- Comparison of microdissection testicular sperm extraction, conventional testicular sperm extraction, and testicular sperm aspiration for nonobstructive azoospermia: a systematic review and meta-analysis.Fertil Steril. 2015; 104 (1099-103.e1-3)
- Predictive factors of successful microdissection testicular sperm extraction.Basic Clin Androl. 2013; 23: 5
- Factors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients.Clin Exp Reprod Med. 2017; 44: 22-27
- Structural and functional changes to the testis after conventional versus microdissection testicular sperm extraction.Urology. 2005; 65: 1190-1194
- Predictors of testicular sperm retrieval in patients with non-obstructive azoospermia: a review.J Int Med Res. 2021; 493000605211002703
- Imaging and angiography in male factor infertility.Fertil Steril. 2016; 105: 1432-1442
- Novel methods to enhance surgical sperm retrieval: a systematic review.Arab J Urol. 2021; 19: 227-237
- Ultrasound evaluation of seminiferous tubules: a promising prognostic tool for men with nonobstructive azoospermia undergoing microsurgical testicular sperm extraction.Fertil Steril. 2020; 113: 73-74
- Ultrasonographically determined size of seminiferous tubules predicts sperm retrieval by microdissection testicular sperm extraction in men with nonobstructive azoospermia.Fertil Steril. 2020; 113 (e2): 97-104
- Assessment of the use of contrast enhanced ultrasound in guiding microdissection testicular sperm extraction in nonobstructive azoospermia.BMC Urol. 2018; 18: 48
- Can contrast-enhanced ultrasound increase or predict the success rate of testicular sperm aspiration in patients with azoospermia?.AJR Am J Roentgenol. 2019; : 1-6
- A new power Doppler ultrasound guiding technique for improved testicular sperm extraction.Fertil Steril. 2004; 81: 430-434
- Tissue perfusion-controlled guided biopsies are essential for the outcome of testicular sperm extraction.Fertil Steril. 2007; 87: 1071-1076
- Microdissection testicular sperm extraction (micro-TESE) in men with infertility due to nonobstructive azoospermia: summary of current literature.Int Urol Nephrol. 2021; 53: 2193-2210
- Testicular apparent diffusion coefficient and magnetization transfer ratio: can these MRI parameters be used to predict successful sperm retrieval in nonobstructive azoospermia?.AJR Am J Roentgenol. 2019; 213: 610-618
- A method for utilizing automated machine learning for histopathological classification of testis based on Johnsen scores.Sci Rep. 2021; 11: 9962
- MRI in the evaluation of the azoospermic male.Diagn Interv Radiol. 2020; 26: 271-276
- The history of microsurgery in urology.Urology. 2015; 85: 971-975
- Review of the role of robotic surgery in male infertility.Arab J Urol. 2018; 16: 148-156
Systems OM. ORBEYE 4K 3D digital video microscope.
- The risk of ergonomic injury across surgical specialties.PLoS One. 2021; 16e0244868
- Application of the ORBEYE three-dimensional exoscope for microsurgical procedures.Microsurgery. 2020; 40: 468-472
- Comparative assessment of ergonomic experience with heads-up display and conventional surgical microscope in the operating room.Clin Ophthalmol. 2021; 15: 347-356
- Effect of alternative video displays on postures, perceived effort, and performance during microsurgery skill tasks.Appl Ergon. 2016; 53: 281-289
Raman Spectroscopy.https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/raman-spectroscopy
- Advantages and limitations of Raman spectroscopy for molecular diagnostics: an update.Expert Rev Mol Diagn. 2015; 15: 773-787
- Reproductive medicine: still more ART than science?.BJOG. 2019; 126: 138-141
- The Prevalence of Y-chromosome Microdeletions in Oligozoospermic Men: A Systematic Review and Meta-analysis of European and North American Studies.Eur Urol. 2019; 76 (Epub 2019 Aug 8. PMID: 31400948): 626-636https://doi.org/10.1016/j.eururo.2019.07.033
- Sperm selection methods in the 21st century.Biol Reprod. 2019; 101: 1076-1082
- Simulating nature in sperm selection for assisted reproduction.Nat Rev Urol. 2022; 19: 16-36
- A microfluidic sperm-sorting device reduces the proportion of sperm with double-stranded DNA fragmentation.Zygote. 2022; 30: 200-205
- Application of stacked convolutional and long short-term memory network for accurate identification of CAD ECG signals.Comput Biol Med. 2018; 94: 19-26
- A prospective study on the predictive value of normal sperm morphology as evaluated by computer (IVOS).Fertil Steril. 1996; 66: 285-291
- SpermQ(-)A simple analysis software to comprehensively study flagellar beating and sperm steering.Cells. 2018; 8
- Rapid sperm capture: high-throughput flagellar waveform analysis.Hum Reprod. 2019; 34: 1173-1185
- Sperm DNA integrity assays: diagnostic and prognostic challenges and implications in management of infertility.J Assist Reprod Genet. 2011; 28: 1073-1085
- Deep learning-based selection of human sperm with high DNA integrity.Commun Biol. 2019; 2: 250
Article info
Publication history
Published online: July 25, 2022
Accepted:
June 12,
2022
Received:
February 24,
2022
Footnotes
All other authors have no conflicts of interest to disclose.
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
