We appreciate the insightful comments from Dr. Russo underlining the need for careful consideration regarding the optimal management strategy for newly diagnosed renal masses. Given the prevalence of comorbid conditions, such as hypertension and diabetes, among adults in the United States and the growing use of cross-sectional imaging, urologists increasingly encounter adults with renal malignancy and preexisting chronic kidney disease (CKD). Consideration of both operative and non-operative interventions based on the size and location of the renal mass, competing comorbidities, expected renal function outcomes, and life expectancy remains prudent.
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        • Bhindi B
        • Lohse CM
        • Schulte PJ
        • et al.
        Predicting renal function outcomes after partial and radical nephrectomy.
        Eur Urol. 2019; 75: 766-772
        • Shum CF
        • Bahler CD
        • Cary C
        • et al.
        Preoperative nomograms for predicting renal function at 1 year after partial nephrectomy.
        J Endourol. 2017; 31: 711-718
        • Campell SC
        • Clark PE
        • Chang SS
        • et al.
        Renal mass and localized renal cancer: evaluation, management, and follow-up: AUA guideline part I.
        J Urol. 2021; 206: 199
        • Alam R
        • Patel HD
        • Osumah T
        • et al.
        Comparative effectiveness of management options for patients with small renal masses: a prospective cohort study.
        BJU Int. 2019; 123: 42-50
        • Uzosike AC
        • Patel HD
        • Alam R
        • et al.
        Growth kinetics of small renal masses on active surveillance: variability and results from the DISSRM registry.
        J Urol. 2018; 199: 641-648
        • Marzouk K
        • Tin A
        • Liu N
        • et al.
        The natural history of large renal masses followed on observation.
        Urol Oncol. 2018; 36: 362.e17-362.e21
        • Tonelli M
        • Wiebe N
        • Culleton B
        • et al.
        Chronic kidney disease and mortality risk: a systematic review.
        J Am Soc Nephrol. 2006; 17: 2034-2047
        • Go AS
        • Chertow GM
        • Fan D
        • McCulloch CE
        • Hsu CY.
        Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization.
        N Engl J Med. 2004; 351: 1296-1305
        • Ferro CJ
        • Townend JN.
        Risk for subsequent hypertension and cardiovascular disease after living kidney donation: is it clinically relevant?.
        Clin Kidney J. 2021; 15: 644-656
        • Ellis RJ.
        Chronic kidney disease after nephrectomy: a clinically-significant entity?.
        Transl Androl Urol. 2019; 8: S166-SS74
        • Wu J
        • Suk-Ouichai C
        • Dong W
        • et al.
        Analysis of survival for patients with chronic kidney disease primarily related to renal cancer surgery.
        BJU Int. 2018; 121: 93-100