OBJECTIVE
To propose a conceptual model to identify points along the condition course where
actions or inaction affect downstream burdens of non–cancerous genitourinary conditions
(NCGUC).
MATERIALS AND METHODS
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) convened
an interdisciplinary meeting to comprehensively consider the burdens of NCGUCs. Subsequently,
the authors met monthly to conceptualize the model.
RESULTS
Inflection points (IP) describe time points during a condition course that are sensitive
to change. Our proposed Inflection Point Model (IPM) helps conceptualize burden/benefit
trade-offs in any related decision and provides a platform to identify the downstream
aggregate burden of a NCGUC across multiple socio-ecological levels at a single time
point, which may be summed across the condition course to measure cumulative burden.
Two personae demonstrate the utility of this model to better understand impacts of
2 common NCGUCs.
CONCLUSION
The IPM may be applied in multiple contexts: narrowly to explore burden of a single
NCGUC at a single IP; or more broadly, to address multiple conditions, multiple IPs,
or multiple domains/levels of social ecology. Applying the IPM may entail combining
population data describing prevalence of NCGUCs, associated behaviors, and resulting
outcome patterns that can be combined with suitable mathematical models to quantify
aggregate and cumulative burden. The IPM challenges stakeholders to expand from the
individual to include broader levels of social ecology. Application of the IPM will
undoubtedly identify data gaps and research needs that must be fulfilled to delineate
and address the burden of NCGUCs.
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Article info
Publication history
Published online: August 10, 2021
Accepted:
July 29,
2021
Received:
April 5,
2021
Footnotes
Financial and Personal Disclosures: Jenna M. Norton: None; Annemarie Dowling-Castronovo: None; Britt Conroy: None; Adonis K. Hijaz: Collamedix Inc (equity) and Astellas (speaker); Michelle Kim: None; Christine N. Loizou: None; David E Meyer: None; Melissa L. Constantine: None
Identification
Copyright
Published by Elsevier Inc.
