Objective
To investigate the association between paternal race and reproductive outcomes following
in vitro fertilization (IVF).
Materials and Methods
We compared demographic and clinical characteristics, IVF cycle characteristics, and
reproductive outcomes (pregnancy, miscarriage, and live birth), stratified by male
and female partner race, for all IVF cycles performed at our institution between 2014
and 2019. Wilcoxon Rank Sum test and Pearson's Chi Square test were used to compare
continuous and categorical data, respectively. A Poisson regression model was used
to determine the association between race and clinical outcomes. Significance was
set as P <.05.
Results
We examined 1878 IVF cycles involving 1069 couples. The study population was diverse;
50.1% of male partners were white, 28.5% black, 15.1% Asian, and 2.3% Hispanic. The
majority of couples (86.5%) shared a common self-reported race category. Black males
were older than white males (39.6 vs 37.0 years), with higher BMI (30.4 vs 28.0) and
higher frequency of male factor infertility (45.9% vs 33.5%). Female partners of black
males were older than those of white males (35.6 vs 33.8 years), with higher BMI (29.6
vs 25.2), and higher frequency of female factor infertility (91.8% vs 83.9%). Although
we noted race-related variability in IVF cycle characteristics, no significant differences
in the outcomes of pregnancy, biochemical pregnancy, clinical intrauterine pregnancy,
or ectopic pregnancy were observed between races.
Conclusion
Although paternal race was associated with IVF cycle characteristics, after controlling
for potential confounders, paternal race did not independently contribute to outcomes
in this institutional dataset.
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Article info
Publication history
Published online: July 19, 2021
Accepted:
May 17,
2021
Received:
January 27,
2021
Footnotes
Financial Disclosure: The authors declare that they have no relevant financial interests
Funding Support: This work was supported by the 2020 Urology Care Foundation Summer Medical Student Fellowship Program
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
