Objectives
To investigate the impact of age on the relationship between obstructive sleep apnea
syndrome (OSAS), nocturia, and other lower urinary tract symptoms (LUTSs).
Methods
This was a secondary analysis study based on data derived from a previously conducted
prospective observational cohort study on OSAS and nocturia. We analyzed 90 subjects
who were suspected of having OSAS. Prior to polysomnography, we assessed International
Prostate Symptom Score-Quality of Life scores, Overactive Bladder Symptom Scores,
and International Consultation on Incontinence Modular Questionnaire-Nocturia Quality
of Life scores to evaluate LUTSs. Nocturnal urine volume, night-time frequency, and
night-time urine electrolyte content were measured during polysomnography. Patients
were divided into groups according to age and OSAS severity determined using apnea-hypopnea
index (AHI) scores. Young patients were those aged <65 years and elderly patients,
≥65 years. A multiple linear regression with multiple imputations was performed to
examine the association of night-time frequency with demographic, polysomnographic,
and clinical characteristics.
Results
In young patients, night-time frequency was significantly associated with nocturnal
urine volume, AHI score, and total IPSS. However, night-time frequency in elderly
subjects was not associated with demographic and polysomnographic characteristics.
In order to compare the severity of OSAS, night-time frequency and urinary sodium
content significantly increased only in young patients (P = .007 and .004, respectively).
Conclusion
OSAS is a strong candidate of causative factor for nocturia in younger individuals.
When a younger patient complains nocturia without any urological disorders, OSAS should
be kept in mind as a potential cause of nocturia.
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Article Info
Publication History
Published online: May 28, 2020
Accepted:
April 30,
2020
Received:
December 27,
2019
Footnotes
Competing interests: The authors have no competing interests.
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
