Abstract
Objective
To determine the relationship between subcutaneous fat, visceral fat surface area
(VFA), bladder wall fat distribution, and visceral adiposity index (VAI) as risk factors
for overactive bladder (OAB) occurrence.
Patients and Methods
A cross-sectional study involved 157 participants was conducted. The participants
were divided into 2 groups; study group (87 patients diagnosed with OAB) and control
group (70 healthy participants). All participants were evaluated for OAB using short-form
OABSS version. Physical examination including waist circumference (WC) measurement
in addition to metabolic laboratory investigations (eg, High density lipoprotein (HDL),
cholesterol, etc) were done. Study group underwent urodynamic testing. Using noncontrast
spiral CT abdomen and pelvis, trunkal fat measurements and bladder wall fat distribution
were detected. VAI was calculated for both females and males. Univariate and multivariate
analyses were done to detect risk factors for OAB occurrence. Correlation between
all factors and total OABSS and urodynamics was done.
Results
The mean age ± SD was 40.4 ± 9 years. In multivariate analysis, increased VFA, higher
cholesterol level, increased VAI and focal fat distribution at bladder wall were associated
with 9.4, 1.98, 5.5, and 1.6 times higher risk for OAB occurrence. VAI and VFA were
strongly correlated with total OABSS, DLPP, amplitude, and frequency of bladder detrusor
contractions. On the other hand, WC and body mass index were not correlated significantly.
Conclusion
Body mass index and WC are crude inaccurate methods correlated with OAB presence.
Focal bladder wall fat distribution, higher VAI, higher VFA are novel risk factors
for OAB occurrence. Both VAI and VFA are correlated significantly to total OABSS and
urodynamics findings in patients with OAB.
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Article info
Publication history
Published online: May 28, 2020
Accepted:
April 29,
2020
Received:
January 8,
2020
Footnotes
Clinical trial no: NCT03750604.
Identification
Copyright
© 2020 Elsevier Inc. All rights reserved.
