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Historical Perspective on Partial Nephrectomy and Renal Functional Preservation

  • Paul Russo
    Correspondence
    Address correspondence to: Paul Russo, M.D., Weill Cornell School of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065.
    Affiliations
    Weill Cornell School of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY
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      In this 2002 study from Memorial Sloan Kettering Cancer Center we evaluated the renal functional impact of partial nephrectomy (PN) or radical nephrectomy (RN) for renal tumors of 4 cm or less. We reported that RN patients were more likely to develop renal insufficiency as defined by a serum creatinine of > 2.0 mg/dL.
      • McKiernan J
      • Simmons R
      • Katz J
      • Russo P
      Natural history of chronic renal insufficiency after partial and radical nephrectomy.
      This result confirmed similar findings reported from Mayo Clinic
      • Lau WK
      • Blute ML
      • Weaver AL
      • et al.
      Matched comparison of radical nephrectomy vs. nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contra lateral kidney.
      and both studies brought new concerns for the preservation of renal function into sharp focus for urologists performing kidney tumor operations.
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      Linked Article

      • Natural history of chronic renal insufficiency after partial and radical nephrectomy
        UrologyVol. 59Issue 6
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          Objectives. To compare the incidence of newly developed chronic renal insufficiency after partial nephrectomy (PN) and radical nephrectomy (RN). Elective PN for renal tumors is intended to preserve renal function; however, studies of transplant donors suggest normal renal function is also maintained after unilateral nephrectomy.Methods. We retrospectively compared all patients undergoing PN or RN for renal tumors 4 cm or less in the presence of a normal contralateral kidney from 1989 to 2000. Creatinine failure was defined as a serum creatinine value greater than 2.0 mg/dL.
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