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Role of Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Bladder Pain Syndrome/Interstitial Cystitis

      Abstract

      Some recent studies evaluated the introduction of diffusion-weighted magnetic resonance imaging (DW-MRI) in the diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC).

      Objective

      To evaluate whether DW-MRI can contribute to noninvasive diagnosis of BPS/IC. The agreement between two raters (2 radiologists involved in the study) was also evaluated, the relevance of the "operator-dependent" factor defined.

      Patients and Methods

      Twenty-two female patients with a diagnosis of BPS-IC were recruited and performed DW-MRI. The same investigation was also performed in 20 patients with pelvic gynecological diseases and no BPS-IC.

      Results

      A significant difference was found between BPS-IC and no-BPS-IC since 17 out of 22 subjects of the first group were positive, compared to 3 out of 20 no-IC subjects, with a P value of .001 to highlight the statistical significance. The sensitivity of the exam was 77%, while the specificity was 85%. There was good agreement between the 2 raters in the evaluation of MRI results.

      Conclusion

      DW-MRI helps to obtain a noninvasive diagnosis of BPS/IC, by providing useful information on the choice of which patients may be more appropriately submitted to cystoscopy and bladder biopsy.
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      References

      1. van de Merwe JP. Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol2008. doi:10.1016/j.eururo.2007.09.019.

        • Oravisto KJ
        Epidemiology of interstitial cystitis.
        Ann Chir Gynaecol Fenn. 1975; 69: 75-77
        • Towner RA
        • Wisniewski AB
        • Wu DH
        • et al.
        A feasibility study to determine whether clinical contrast enhanced magnetic resonance imaging can detect increased bladder permeability in patients with interstitial cystitis.
        J Urol. 2016; https://doi.org/10.1016/j.juro.2015.08.077
        • Charlanes A
        • Boudghene F
        • Chesnel C
        • et al.
        Diffusion-weighted magnetic resonance imaging: a new tool for the diagnosis of bladder pain syndrome/interstitial cystitis.
        Urol Int. 2019; 102: 109-112
        • van de Merwe J
        • Nordling J
        • Bouchelouche P
        • et al.
        Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal.
        Eur Urol. 2008; 53 (Epub 2007 Sep 20): 60-67
        • Thoeny HC
        • Forstner R
        • De Keyzer F
        Genitourinary applications of diffusion-weighted MRI imaging in the Pelvis.
        Radiology. 2012; 263: 326-342
        • Fujii S
        • Matsusue E
        • Kigawa J
        • et al.
        Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results.
        Eur Radiol. 2008; 18: 384-389
        • Takeuchi M
        • Matsuzaki K
        • Nishitani H
        Diffusion-weighted magnetic resonance imaging of endometrial cancer: differentiation from benign endometrial lesions and preoperative assessment of myometrial invasion.
        Acta Radiol Stockh Swed 1987. 2009; 50: 947-953
        • Takeuchi M
        • Sasaki S
        • Ito M
        • et al.
        Urinary bladder cancer: diffusion-weighted MR imaging—accuracy for diagnosing T stage and estimating histologic grade.
        Radiology. 2009; 251: 112-121
        • Yoshida S
        • Koga F
        • Kawakami S
        • et al.
        Initial experience of diffusion-weighted magnetic resonance imaging to assess therapeutic response to induction chemoradiotherapy against muscle-invasive bladder cancer.
        Urology. 2010; 75: 387-391