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Questions and Answers: Finasteride Label Changes. U.S. Department of Health & Human Services, 2012. (Accessed 6/15/15, at http://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm299754.htm)
- Whitehouse Station.Merk Sharp & Dohme Corp., NJ, USA2010 (October)
- The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases.Adv Urol. 2012; 2012: 18
- Research Triangle Park NC, USA: GlaxoSmithKline;. 2008;
- Update on AUA guideline on the management of benign prostatic hyperplasia.J Urol. 2011; 185: 1793-1803
- Sexual Medicine Society of North America 5ARI Colloquium Registry Group, Meeting Transcript. Washington, D.C.2014
- Accessed June 17, 2015, at)http://www.pfsfoundation.org/Date: 2013 (
- 5 alpha-reductase inhibitors alter steroid metabolism and may contribute to insulin resistance, diabetes, metabolic syndrome and vascular disease: a medical hypothesis.Horm Mol Biol Clin Investig. 2014; 20: 73-80
- 5alpha-reductase type 1 modulates insulin sensitivity in men.J Clin Endocrinol Metab. 2014; 99: E1397-E1406
- Psychological aspects of hair disease.J Cosmet Dermatol. 2005; 4: 142-147
- Finasteride induced depression: a prospective study.BMC Clin Pharmacol. 2006; 6: 7
- Finasteride-induced depression: new insights into possible pathomechanisms.J Cosmet Dermatol. 2010; 9: 331-332
- Finasteride treatment inhibits adult hippocampal neurogenesis in male mice.Pharmacopsychiatry. 2010; 43: 174-178
- Neuroactive steroid levels are modified in cerebrospinal fluid and plasma of post-finasteride patients showing persistent sexual side effects and anxious/depressive symptomatology.J Sex Med. 2013; 10: 2598-2603
- Depression circumstantially related to the administration of finasteride for androgenetic alopecia.J Dermatol. 2002; 29: 665-669
- Adverse side effects of 5alpha-reductase inhibitors therapy: persistent diminished libido and erectile dysfunction and depression in a subset of patients.J Sex Med. 2011; 8: 872-884
- Finasteride treatment and neuroactive steroid formation.Prague Med Rep. 2009; 110: 222-230
- Neurosteroid metabolism in the human brain.Eur J Endocrinol Eur Feder Endocr Soc. 2001; 145: 669-679
- Neurosteroids, neuroactive steroids, and symptoms of affective disorders.Pharmacol Biochem Behav. 2006; 84: 644-655
- Persistent sexual side effects of finasteride: could they be permanent?.J Sex Med. 2012; 9: 2927-2932
- Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects.J Clin Psychiatry. 2012; 73: 1220-1223
- Persistent sexual, emotional, and cognitive impairment post-finasteride: a survey of men reporting symptoms.Am J Men Health. 2015; 9: 222-228
- Adverse event reporting in clinical trials of finasteride for androgenic alopecia: a meta-analysis.JAMA Dermatol. 2015; 151: 600-606
- The efficacy and safety of 5alpha-reductase inhibitors in androgenetic alopecia: a network meta-analysis and benefit-risk assessment of finasteride and dutasteride.J Dermatol Treat. 2014; 25: 156-161
- Persistent sexual dysfunction with finasteride 1 mg taken for hair loss.Pharmacotherapy. 2016; 36: 1180-1184
- Risk of erectile dysfunction associated with use of 5-alpha reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink.BMJ (Clin Res Ed). 2016; 354: i4823
- Finasteride 5 mg and sexual side effects: how many of these are related to a nocebo phenomenon?.J Sex Med. 2007; 4: 1708-1712
- Whitehouse Station. Merk Sharp & Dohme Corp., NJ, USA04, 2012
Conner MW D-CC, Green LC, Armstrong SR, Taniguchi C, Tashijan AH, and Golan DE. Drug toxicity. principles of pharmacology: the pathophysiologic basis of drug therapy. 3 ed. 2011:56-70.
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Conflict of Interest: KTM: Retained as expert in litigation involving finasteride by Merck Inc. No other conflicts noted for other authors.