Objective
To evaluate the risk of long-term tumor recurrence and progression in patients with
low- and intermediate-risk non-muscle-invasive bladder cancers, which could facilitate
optimization in the follow-up schedules.
Materials and Methods
A single-institution, retrospective analysis of 704 patients with primary TaG1, TaG2,
T1G1, and T1G2 urothelial carcinomas of the bladder without concomitant carcinoma
in situ, treated with transurethral resection, was performed. Response was determined
and monitored by routine periodic urine cytology, cystoscopy, and upper tract imaging.
Results
The median follow-up was 64.9 months (maximum, 120 months). Among all of the tumors,
59.3% did not relapse, 36.6% recurred in the bladder during the first 5 years of surveillance,
and only 3.6% recurred after 5 years of follow-up. Eight urothelial bladder cancers
(1.1%) progressed in stage, and 87.5% of the progressions occurred during the first
5 years of surveillance. An upper urinary tract recurrence was detected in 2.4% of
the patients; 94.1% were diagnosed within the upper urinary tract during the first
5 years of follow-up and 5.9% occurred after 5 years of surveillance.
Conclusion
G1-2 urothelial bladder cancers recur and progress uncommonly in the long-term period.
Although limited by its retrospective nature, the present study provides potential
grounds for re-examination of the follow-up schedule for patients with primary non-muscle-invasive
bladder cancer G1-2 tumors who remain asymptomatic and disease-free for at least 5
years.
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Article info
Publication history
Published online: October 17, 2016
Accepted:
July 23,
2016
Received:
March 23,
2016
Footnotes
Financial Disclosure: The authors declare that they have no relevant financial interests.
Identification
Copyright
© 2016 Elsevier Inc. All rights reserved.
