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Editorial Comment

      The article by Thomas et al
      • Thomas A.A.
      • Wallner L.P.
      • Quinn V.P.
      • et al.
      Association between cannabis use and the risk of bladder cancer: results from the California Men's Health Study.
      lays out the scientific basis for a possible relationship between cannabinoids and the development of bladder cancer. Cannabinoid receptors have been identified in the bladder and appear to be mediators of the inflammatory response. There is evidence that cannabinoids inhibit cell growth in human and murine bladder cancer cell lines.
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      Reference

        • Thomas A.A.
        • Wallner L.P.
        • Quinn V.P.
        • et al.
        Association between cannabis use and the risk of bladder cancer: results from the California Men's Health Study.
        Urology. 2015; 85: 388-393

      Linked Article

      • Association Between Cannabis Use and the Risk of Bladder Cancer: Results From the California Men's Health Study
        UrologyVol. 85Issue 2
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          To investigate the association of cannabis use and tobacco smoking on the incidence of bladder cancer within the California Men's Health Study cohort.
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        UrologyVol. 85Issue 2
        • Preview
          Tobacco smoking is a well-established risk factor for the development of bladder cancer; however, little is known about the contribution of cannabis use to the incidence of bladder cancer. There is mounting evidence demonstrating antitumor properties of cannabinoids, which are the active components of the cannabis plant Cannabis sativa. Therefore, cannabis use may not mimic the adverse effects of tobacco smoking on the bladder and may mitigate the risk of bladder cancer associated with tobacco smoking.
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