Objective
To study the significance of measurements of plasma leptin and 5-hydroxytryptamine
(5-HT) levels in the diagnosis of premature ejaculation (PE).
Methods
We compared plasma leptin and 5-HT levels, intravaginal ejaculation latency time (IELT)
and Chinese Index of Premature Ejaculation-5 (CIPE-5) scores between 59 patients with
PE and 64 healthy control men without PE. We then analyzed the correlations of plasma
leptin and 5-HT levels with the IELT and CIPE-5 scores. The patients with PE were
administered sertraline (50mg daily) for 8 weeks, and their plasma leptin and 5-HT
levels, CIPE-5 scores and IELT were measured again. Comparative analyses of the data
were performed between the experimental and control groups and between the pre- and
post-treatment values.
Results
Plasma leptin levels were significantly higher (P <.0001), whereas plasma 5-HT levels (P <.0001), IELT (P <.0001), and CIPE-5 scores (P <.0001) were significantly lower in the experimental group than in the control group.
Significant changes in leptin and 5-HT levels, IELT and CIPE-5 scores were observed
after treatment in the experimental group. Plasma leptin levels negatively correlated
with 5-HT levels, CIPE-5 scores, and IELT, whereas 5-HT levels positively correlated
with IELT and CIPE-5 scores.
Conclusion
Plasma leptin and 5-HT levels indicate the presence of PE and can be used as diagnostic
markers for PE.
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Article info
Publication history
Published online: October 14, 2013
Accepted:
August 4,
2013
Received:
May 12,
2013
Footnotes
Financial Disclosure: The authors declare that they have no relevant financial interests.
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
