Advertisement

Serum Leptin and 5-Hydroxytryptamine Measurements for the Diagnosis and Treatment of Premature Ejaculation

Published:October 14, 2013DOI:https://doi.org/10.1016/j.urology.2013.08.009

      Objective

      To study the significance of measurements of plasma leptin and 5-hydroxytryptamine (5-HT) levels in the diagnosis of premature ejaculation (PE).

      Methods

      We compared plasma leptin and 5-HT levels, intravaginal ejaculation latency time (IELT) and Chinese Index of Premature Ejaculation-5 (CIPE-5) scores between 59 patients with PE and 64 healthy control men without PE. We then analyzed the correlations of plasma leptin and 5-HT levels with the IELT and CIPE-5 scores. The patients with PE were administered sertraline (50mg daily) for 8 weeks, and their plasma leptin and 5-HT levels, CIPE-5 scores and IELT were measured again. Comparative analyses of the data were performed between the experimental and control groups and between the pre- and post-treatment values.

      Results

      Plasma leptin levels were significantly higher (P <.0001), whereas plasma 5-HT levels (P <.0001), IELT (P <.0001), and CIPE-5 scores (P <.0001) were significantly lower in the experimental group than in the control group. Significant changes in leptin and 5-HT levels, IELT and CIPE-5 scores were observed after treatment in the experimental group. Plasma leptin levels negatively correlated with 5-HT levels, CIPE-5 scores, and IELT, whereas 5-HT levels positively correlated with IELT and CIPE-5 scores.

      Conclusion

      Plasma leptin and 5-HT levels indicate the presence of PE and can be used as diagnostic markers for PE.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Urology
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Carson C.
        • Gunn K.
        Premature ejaculation: definition and prevalence.
        Int J lmpot Res. 2006; 18 (PMID: 16953247PE): S5-S13
        • Waldinger M.D.
        The neurobiological approach to premature ejaculation.
        J Urol. 2002; 168: 2359-2367
        • Waldinger M.D.
        • Berendsen H.H.
        • Blok B.F.
        • et al.
        Premature ejaculation and serotonergic antidepressants-induced delayed ejaculation: the involvement of the serotonergic system.
        Behav Brain Res. 1998; 92: 111-118
        • Atmaca M.
        • Kuloglu M.
        • Tezcan E.
        • et al.
        Serum leptin levels in patients with premature ejaculation before and after citalopram treatment.
        BJU Int. 2003; 91: 252-254
        • Atmaca M.
        • Kuloglu M.
        • Tezcan E.
        Serum leptin levels in patients with premature ejaculation.
        Arch Androl. 2002; 48: 345-350
        • Andrology group of Professional Committee of Society of Sexual Medicine of China
        Guideline of premature ejaculation diagnosis and treatment.
        National Journal of Andrology. 2011; 17: 1043-1049
        • Althof S.E.
        • Symonds T.
        Patient reported outcomes used in the assessmentof premature ejaculation.
        Urol Clin North Am. 2007; 34 (vii): 581-589
        • Xue J.
        • Chen L.S.
        • Ding X.G.
        • et al.
        Progress in the studies of premature ejaculation.
        National Journal of Andrology. 2007; 13: 65-68
        • Coolen L.M.
        • Peters H.J.
        • Veening J.G.
        Defining premature ejaculation for experimental and clinical investigations.
        Arch Sex Behav. 2001; 30: 235-253
        • Yells D.P.
        • Prendergast M.A.
        • Hendricks S.E.
        • et al.
        Fluoxetine-induced inhibition of male rat copulatory behavior: modification by lesions of the nucleus paragigantocellularis.
        Phannacol Biochem Behav. 1994; 49: 121-127
        • McMahon C.G.
        Premature ejaculation.
        Indian J Urol. 2007; 23: 97-108
        • Sharlip I.
        Diagnosis and treatment of premature ejaculation: the physician's perspective.
        J Sex Med. 2005; 2: 103-109
        • Olivier B.
        • Chan J.S.
        • Pattij T.
        • et al.
        Psychopharmacoiogy of male rat sexual behavior: modeling 10human sexual dysfunction?.
        Int J Impot Res. 2006; 18: S14-S23
        • Waldinger M.D.
        • Hengeveld M.W.
        • Zw inderman A.H.
        • et al.
        Effect of SSRI an tidepressants on ejaculation: a double-blind, randomized, placebo-controlled study with fluoxetine, fluvoxamine, paroxetine, and sertraline.
        J Clin Psychopharmaco. 1998; 18: 274-281
        • Biri H.
        • Isen K.
        • Sinik Z.
        • et al.
        Sertraline in the treatment of premature ejaculation: a double-blind placebo controlled study.
        Int Urol Nephrol. 1998; 30: 611-615
        • Mc Mahon C.G.
        Treatment of premature ejaculation with sertraline hydrochloride: a single-blind placebo controlled crossover study.
        J Urol. 1998; 159: 1935-1938
        • Novaretti J.P.T.
        • Pompeo A.C.L.
        • Arap S.
        Selective seroton in re-uptake in hibitor in the treatment of premature ejaculation.
        Braz J Urol. 2002; 28: 116-122
        • Pan S.H.
        • Xie L.P.
        The efficacy of fluoxetine in the treatment of premature ejaculation.
        J Clin Urol. 2004; 19: 400-401
        • Mattos R.M.
        • Marmo Lucon A.
        • Srougi M.
        Tadalafil and fluoxetine in premature ejaculation: prospective, randomized, double-blind, placebo-controlled study.
        Urologia Internationalis. 2008; 80: 162-165
        • Zhang Y.
        • Proenca R.
        • Maffei M.
        • et al.
        Positional cloning of the mouse obese gene and its human homologue.
        Nature. 1994; 372: 425-432
        • Halaas J.L.
        • Gajiwala K.S.
        • Maffei M.
        • et al.
        Weight-reducing effects of the plasma protein encoded by the obese gene.
        Sience. 1995; 269: 543-546
        • Prolo P.
        • Wong M.L.
        • Licinio J.
        Leptin.
        Int J Biochem Cell Biol. 1998; 30: 1285-1290
        • Hastings J.A.
        • Wiesner G.
        • Lambert G.
        • et al.
        Influence of leptin on neurotransmitter overflow from the rat brain in vitro.
        Tegul Pept. 2002; 103: 67-74
        • Guadalupe G.
        • Angelina R.
        • Paulina M.
        • et al.
        Serotonin receptor 5-HT5A in rat hippocampus decrease by leptin treatment.
        NeurosciLett. 2010; 486: 171-173
        • Banks W.A.
        • McLay R.N.
        • Kastin A.J.
        • et al.
        Passage of leptin across the blood-testis barrier.
        Am J Physiol. 1999; 276: E1099-E1104
        • Rodrnguez A.
        • Fortuno A.
        • Gomez-Ambrosi J.
        • et al.
        The inhibitory effect of leptin on angiotensin IIinduced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism.
        Endocrinology. 2007; 148: 324-331