In the spectrum of BPS, IC is still a pathophysiologic enigma and its treatment empirical. Simplistically, it is considered to be result of a multifactorial cascade of events that culminate into an imbalance of the damage-repair process of the urothelium, leading to deficiency of the GAG layer and the resulting symptoms. Various oral and intravesical GAG analogs have been in clinical use, most notably pentosan polysulphate (oral), hyaluronic acid (intravesical), and heparin (intravesical). Of these, only pentosan polysulphate has been subject to comprehensive scrutiny through randomized placebo-controlled trials, the results of which have been published in peer-reviewed reports. Its efficacy has been reported to be moderate at best.
1In this regard, the authors must be complimented for conducting a very well-designed, double-blind, placebo-controlled trial on another GAG analog chondroitin sulphate and reaffirming the inefficacy of this medication. Therefore, despite the pathologic proof of GAG deficiency, none of the available GAG analogs have proved to have robust activity in controlling the symptoms.
- Davis E.L.
- El Khoudary S.R.
- Talbott E.O.
- et al.
Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial.
J Urol. 2008; 179: 177-185
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- Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial.J Urol. 2008; 179: 177-185
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Published online: April 18, 2012
© 2012 Elsevier Inc. Published by Elsevier Inc. All rights reserved.