Male infertility is a multifactorial condition with a strong genetic component. In
the last decade a large number of investigations focused on the identification of
gene variants affecting spermatogenesis in human. Polymorphisms of the estrogen receptor
(ER) genes, have been implicated in male infertility; however, comprehensive data
are lacking. We investigated the association between the ER-α gene (ESR1) PvuII and
XbaI and ER-β gene (ESR2) RsaI and Alul polymorphisms and the idiopathic male infertility
in Iranian males.
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© 2011 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
