We describe 2 cases of patients referred for evaluation of male infertility who had
antidepressant medication-associated changes in sperm motility and/or concentration.
The physical examination and endocrinologic study findings were unremarkable in each
case. Analysis of the initial semen specimens revealed oligospermia, impaired motility,
and abnormal morphology in each patient while they were taking serotonin reuptake
inhibitors. Repeat semen analyses performed 1 to 2 months after discontinuation of
the antidepressants demonstrated marked improvements in sperm concentration and motility.
Additional assessment of the potential impact of antidepressant medications on male
fertility is warranted.
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Article info
Publication history
Accepted:
October 24,
2006
Received:
April 28,
2006
Identification
Copyright
© 2007 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
