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Antidepressant-Associated Changes in Semen Parameters

  • Author Footnotes
    1 C. Tanrikut is supported by The Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust.
    Cigdem Tanrikut
    Correspondence
    Address for correspondence: Cigdem Tanrikut, M.D., New York Presbyterian Hospital/Weill Medical College, 525 East 68th Street, Starr 900, New York, NY 10021.
    Footnotes
    1 C. Tanrikut is supported by The Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust.
    Affiliations
    James Buchanan Brady Foundation, Department of Urology, New York-Presbyterian Hospital/Weill Medical College of Cornell University, New York, New York, USA; and Center for Biomedical Research, The Population Council, New York, New York.
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  • Peter N. Schlegel
    Affiliations
    James Buchanan Brady Foundation, Department of Urology, New York-Presbyterian Hospital/Weill Medical College of Cornell University, New York, New York, USA; and Center for Biomedical Research, The Population Council, New York, New York.
    Search for articles by this author
  • Author Footnotes
    1 C. Tanrikut is supported by The Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust.
      We describe 2 cases of patients referred for evaluation of male infertility who had antidepressant medication-associated changes in sperm motility and/or concentration. The physical examination and endocrinologic study findings were unremarkable in each case. Analysis of the initial semen specimens revealed oligospermia, impaired motility, and abnormal morphology in each patient while they were taking serotonin reuptake inhibitors. Repeat semen analyses performed 1 to 2 months after discontinuation of the antidepressants demonstrated marked improvements in sperm concentration and motility. Additional assessment of the potential impact of antidepressant medications on male fertility is warranted.
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