Abstract
Objectives
To determine the minimal time to successful intercourse after taking sildenafil citrate
for erectile dysfunction (ED).
Methods
Male patients with ED (mean age 60 years; mean ED duration 7.0 years) who were successfully
treated with sildenafil (100 mg) for 2 months or longer were randomized to sildenafil
(n = 115) or placebo (n = 113) for 4 weeks of double-blind treatment. Using a stopwatch,
patients recorded the time needed to obtain an erection hard enough for sexual intercourse
after taking the study drug at least 2 hours after eating.
Results
Within 14 and 20 minutes of sildenafil dosing, 35% and 51% of sildenafil-treated patients,
respectively, versus 22% and 30% of placebo-treated patients, respectively, had an
erection that led to successful intercourse (P <0.05 for both). The median time to erection leading to successful intercourse after
sildenafil dosing was 36 minutes compared with 141 minutes for placebo.
Conclusions
In this study, slightly more than one half of a population of prior sildenafil responders
achieved an erection that led to successful sexual intercourse within 20 minutes of
sildenafil administration, suggesting that the onset of action of sildenafil can be
less than 30 minutes in men with ED.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to UrologyAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
Pfizer Inc., New York, NY: Data on file. 2002
- Pharmacokinetics of sildenafil citrate after single oral doses in healthy male subjects.Br J Clin Pharmacol. 2002; 53: 5S-12S
- The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil citrate.Br J Clin Pharmacol. 2002; 53: 21S-30S
- The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers.Br J Clin Pharmacol. 2002; 53: 37S-43S
- Onset and duration of action of sildenafil citrate for the treatment of erectile dysfunction.Br J Clin Pharmacol. 2002; 53: 61S-65S
- Sildenafil, a novel effective oral therapy for male erectile dysfunction.Br J Urol. 1996; 78: 257-261
- Oral sildenafil in the treatment of erectile dysfunction.N Engl J Med. 1998; 338: 1397-1404
- The International Index of Erectile Function (IIEF).Urology. 1997; 49: 822-830
- Regression analysis of multivariate incomplete failure time data by modeling marginal distributions.J Am Stat Assoc. 1989; 84: 1065-1073
- Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients.World J Urol. 2001; 19: 32-39
- Tadalafil.Formulary. 2002; 37: 289-296
- Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose.Eur Urol. 2001; 40: 181-190
- Cialis (IC351) provides prompt response and extended period of responsiveness for the treatment of men with erectile dysfunction.J Urol. 2001; 165: 224
Padma-Nathan H, Kaufman J, and Taylor T: Earliest time to onset of erections with vardenafil determined in an at-home setting. Presented at the 28th Annual Meeting of the American Society of Andrology, March 29–April 2, 2003, Phoenix, Arizona
Article info
Publication history
Accepted:
May 19,
2003
Received:
March 6,
2003
Footnotes
☆This study was funded by Pfizer Inc.
☆H. Padma-Nathan is a study investigator funded by the sponsor.
Identification
Copyright
© 2003 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
