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Effects of resiniferatoxin on the neurogenic component of feline interstitial cystitis

      Many of the symptoms and signs of interstitial cystitits (IC) may be due to sensitization of normal afferent pathways that signal bladder distention and pain. We examined the degree of afferent sensitization in a feline model of IC to determine if pain transmission and vesicosympathetic reflexes are upregulated in this disease. We also assessed the relative reduction in afferent transmission and efferent responses after intravesical infusion of resiniferatoxin (RTX) in both normal cats and cats with IC.
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