Objective
To investigate the effects of sertraline on semen parameters and comparison of its
effect with behavioral therapy (BT) in men with primary premature ejaculation.
Methods
In this single-blinded clinical trial, a total of 60 married men with primary premature
ejaculation were randomly divided into 2 groups: the sertraline group (n = 30, sertraline
25 mg/day for 1 week followed by 50 mg/day for 3 months) and the BT group (n = 30,
using BT technique for 3 months). Semen analysis was applied, and the results were
compared between groups before and 3 months after intervention.
Results
The significant reduction in sperm concentration (105/mL) and percentage of normal morphology was reported in sertraline group (P <.05). The percentage of sperm deoxyribonucleic acid fragmentation after intervention
in sertraline group was significantly higher than BT group (P = .004). There was no significant change in semen parameters in patients treated
using BT.
Conclusion
Our study revealed detrimental effects of sertraline on some semen parameters. It
should particularly be considered in patients who are trying to conceive. It seems
BT is a safe method without any side effect on semen analysis parameters.
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References
- Premature ejaculation: definition and drug treatment.Drugs. 2007; 67 (1630-2): 1629-1630
- [Premature ejaculation].Rev Med Brux. 2007; 28 ([in French]): 374-377
- Toward evidence-based genetic research on lifelong premature ejaculation: a critical evaluation of methodology.Korean J Urol. 2011; 52: 1-8
- Premature ejaculation: definition and drug treatment.Drugs. 2007; 67: 547-568
- Sexual dysfunction in the United States: prevalence and predictors.JAMA. 1999; 281: 537-544
- Prevalence of the complaint of ejaculating prematurely and the four premature ejaculation syndromes: results from the Turkish Society of Andrology Sexual Health Survey.J Sex Med. 2011; 8: 540-548
- Premature ejaculation: current and future treatments.Asian J Androl. 2008; 10: 102-109
- Clinical follow-up of couples treated for sexual dysfunction.Arch Sex Behav. 1985; 14: 467-489
- Inverse relationship between physical activity and plasma fibrinogen in postmenopausal women.Atherosclerosis. 1993; 102: 181-186
- New data show declines in antidepressant prescribing.Psychiatr News. 2005; 40: 1-39
- Antidepressant medications, mood and male fertility.Psychoneuroendocrinology. 2000; 25: 37-51
- Antidepressant-associated changes in semen parameters.Urology. 2007; 69 (e5-7): 185
- Chronic pharmacological treatment with certain antidepressants alters the expression and DNA-binding activity of transcription factor AP-2.Life Sci. 2000; 68: 669-678
- Campbell-walsh Urology.10th ed. SUNDERS, 2012
- Comprehensive Textbook of Psychiatry.Lipincott Williams & Wilkins, New York2009
- Sexual dysfunction in primary medical care: prevalence, characteristics and detection by the general practitioner.J Public Health Med. 1997; 19: 387-391
- Relation of mammalian sperm chromatin heterogeneity to fertility.Science. 1980; 210: 1131-1133
- The Premature Ejaculation Prevalence and Attitudes (PEPA) survey: prevalence, comorbidites, and professional help-seeking.Eur Urol. 2007; 51: 816-824
- Premature ejaculation: an observational study of men and their partners.J Sex Med. 2005; 2: 358-367
- Premature ejaculation: results from a five country european observational study.Eur Urol. 2008; 53: 1048-1057
- A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire.Ther Clin Risk Manag. 2007; 3: 527-531
- Incidence of sexual dysfunction associated with antidepressant agents: a prospective multicenter study of 1022 outpatients. Spanish Working Group for the study of psycholotropic-related sexual dysfunction.J Clin Psychiatry. 2001; 62: 10-21
- Sperm DNA damage and semen quality impairment after treatment with selective serotonin reuptake inhibitors detected using semen analysis and sperm chromatin structure assay.J Urol. 2008; 180: 2124-2128
- Adverse effect of paroxetine on sperm.Fertil steril. 2010; 94: 1021-1026
- Escitalopram treatment for premature ejaculation has a negative effect on semen parameters.Int J Impot Res. 2011; 23: 257-261
- Semen parameters are unrelated to BMI but vary with SSRI use and prior urological surgery.Reprod Sci. 2011; 18: 391-397
- Effect of pharmaceutical medications on male Fertility.J Reprod Infertil. 2012; 13: 3-11
- A clinical study on psycho-behavior therapy for premature ejaculation.Zhonghua Nan Ke Xue. 2009; 15: 929-931
- Interventional effect of behaviour psychotherapy on patients with premature ejaculation.Zhonghua Nan Ke Xue. 2006; 12: 717-719
Article info
Publication history
Published online: February 12, 2014
Accepted:
December 3,
2013
Received:
July 23,
2013
Footnotes
Financial Disclosure: The authors declare that they have no relevant financial interests.
Funding Support: The Vice Chancellor for Research of the Kashan University of Medical Sciences provided financial and logistical support for this work.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
