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Abstract
Verrucous carcinoma of the penis (Buschke-Lowenstein tumor) is a rare variant of squamous
cell carcinoma which has been reported to have limited potential for metastatic disease.
We report on 2 patients who presented with locally advanced disease after prolonged
intervals of neglect. In both cases, the disease was locally aggressive with extensive
tissue destruction. In 1 patient, after failure to achieve tumor control with reoeated
aggressive surgical excision, systemic chemotherapy using bleomycin, cisplatin, methotrexate,
and leucovorin led to a complete pathologic response. We believe this is the first
reported case in which systemic chemotherapy has been used to successfully treat verrucous
carcinoma of the penis. Surgical excision alone was successful in achieving local
disease control in the second patient.
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Article info
Publication history
Received in revised form:
June 8,
1993
Received:
June 7,
1993
Identification
Copyright
© 1993 Published by Elsevier Inc.
