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Buschke-lowenstein tumor: Therapeutic options including systemic chemotherapy

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      Abstract

      Verrucous carcinoma of the penis (Buschke-Lowenstein tumor) is a rare variant of squamous cell carcinoma which has been reported to have limited potential for metastatic disease. We report on 2 patients who presented with locally advanced disease after prolonged intervals of neglect. In both cases, the disease was locally aggressive with extensive tissue destruction. In 1 patient, after failure to achieve tumor control with reoeated aggressive surgical excision, systemic chemotherapy using bleomycin, cisplatin, methotrexate, and leucovorin led to a complete pathologic response. We believe this is the first reported case in which systemic chemotherapy has been used to successfully treat verrucous carcinoma of the penis. Surgical excision alone was successful in achieving local disease control in the second patient.
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      References

        • Buschke A.
        Neisser A. Condylomata acuminata. Stereoscopischer Medicinischer Atlas, Fischer, Cassel1896: 98
        • Buschke A.
        • Lowenstein L.
        Uber carcinomahnliche condylomata acuminata des penis.
        Klin Wochenschr. 1925; 4: 1726-1728
        • Lowenstein L.
        Carcinoma-like condylomata acuminata of the penis.
        Med Clin NA. 1939; 23: 789-795
        • McKee P.H.
        • Lowe D.
        • Haigh R.J.
        Penile verrucous carcinoma.
        Histopathology. 1983; 7: 897-906
        • Lowe D.
        • McKee P.H.
        Verrucous carcinoma of the penis (Buschke-Lowenstein tumour): a clinicopathological study.
        Br J Urol. 1983; 55: 427-429
        • Ackerman L.V.
        Verrucous carcinoma of the oral cavity.
        Surgery. 1948; 23: 670-678
        • Elliott G.B.
        • Macdougall J.A.
        • Elliott J.D.A.
        Problems of verrucous squamous carcinoma.
        Ann Surg. 1973; 177: 21-29
        • Newman A.N.
        • Colman M.
        • Jayich S.A.
        Verrucous carcinoma of the frontal sinus: a case report and review of the literature.
        J Surg Oncol. 1983; 24: 298-303
        • Gissmann L.
        • De Villiers E.M.
        • Zur Hausen H.
        Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA.
        Int J Cancer. 1982; 29: 143-146
        • Lehn H.
        • Ernst T.M.
        • Sauer G.
        Transcription of episomal papillomavirus DNA in human condylomata acuminata and Buschke-Lowenstein tumors.
        J Gen Virol. 1984; 65: 2003-2010
        • Redman J.F.
        • Turley J.T.
        Failure of chemotherapy in treatment of giant condylomata acuminata (Buschke-Lowenstein tumor).
        South Med J. 1974; 67: 742-744
        • Dretler S.P.
        • Klein L.A.
        Eradication of intraurethral condyloma acuminata with 5% 5-fluorouracil cream.
        J Urol. 1975; 113: 195-198
        • Carson T.E.
        Verrucous carcinoma of the penis. Successful treatment with cryosurgery and topical fluorouracil therapy.
        Arch Dermatol. 1978; 114: 1546-1547
        • Cheng S.F.
        • Veenema R.J.
        Topical application of thiotepa to penile and urethral tumors.
        J Urol. 1965; 94: 259-262
        • Halverstadt D.B.
        • Parry W.L.
        Thiotepa in the management of intraurethral condylomata acuminata.
        J Urol. 1969; 101: 729-731
        • Harvey J.M.
        • Glen E.
        • Watson G.S.
        Buschke-Loewenstein tumour of the penis, a case report.
        Br J Vener Dis. 1983; 59: 273-276
        • Machacek G.E.
        • Weakley D.R.
        Giant condyloma of Buschke and Lowenstein.
        Arch Dermatol. 1960; 82: 41-47
        • Dawson D.F.
        • Duckworth J.K.
        • Bernhardt H.
        • Young J.M.
        Giant condyloma and verrucous carcinoma of the genital area.
        Arch Pathol. 1965; 79: 225-231
        • Knoblich R.
        • Failing Jr, J.F.
        Giant condyloma acuminatum (Buschke-Lowenstein) tumor of the rectum.
        Am J Clin Pathol. 1967; 48: 389-395
        • McCarron D.L.
        • Carlton C.E.
        Giant condyloma of the penis.
        J Urol. 1970; 104: 730-733
        • Netto Jr, N.R.
        • Chade J.
        • Camargo F.P.
        Giant condylorna or Buschke-Lowenstein tumor.
        Int Surg. 1976; 61: 105-107
        • Bedi T.R.
        • Pandi R.K.
        Buschke-Lowenstein's tumor presenting with urinary fistula.
        Br J Vener Dis. 1977; 53: 200-202
        • Kraus F.T.
        • Perez-Mesa C.
        Verrucous carcinoma. Clinical and pathological study of 105 cases involving oral cavity, larynx and genitalia.
        Cancer. 1966; 19: 26-38
        • Dexeus F.H.
        • Logothetis C.J.
        • Sella A.
        • Amato R.
        • Kilbourn R.
        • Fitz K.
        • Striegel A.
        Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract.
        J Urol. 1991; 146: 1284-1287