Urology
Volume 49, Issue 4 , Pages 508-513 , April 1997

Effect of diabetes mellitus upon male reproductive function

  • Wade J. Sexton
    • ,
  • Jonathan P. Jarow

      Affiliations

    • Corresponding Author InformationReprint requests: Jonathan P. Jarow, M.D., Department of Urology, Wake Forest University Medical Center, Medical Center Boulevard, Winston-Salem, NC 27157-1094

Received 20 August 1996 ,Accepted 29 October 1996.

References 

  1. Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus (review). N Engl J Med. 1994;331:1428–1436
  2. Yki-Jarvinen H. Pathogenesis of non-insulin-dependent diabetes mellitus (review). Lancet. 1994;343:91–95
  3. Gorham ED, Garland FC, Barrett-Connor E, Garland CF, Wingard DL, Pugh WM. Incidence of insulin-dependent diabetes mellitus in young adults: experience of 1,587,630 US Navy enlisted personnel. Am J Epidemiol. 1993;138:984–987
  4. Greenberg SH, Lipshultz LI, Wein AJ. Experience with 425 subfertile male patients. J Urol. 1978;119:507–510
  5. Howland BE, Zebrowski EJ. Some effects of experimentally-induced diabetes on pituitary-testicular relationships in rats. Horm Metab Res. 1976;8:465–469
  6. Howland BE, Zebrowski EJ. Pituitary response to gonadotropin-releasing hormone in diabetic male rats. Experientia. 1980;36:610–611
  7. Perez Diaz J, Benitez A, Fernandez Galaz C. Effect of streptozotocin diabetes on the pituitary-testicular axis in the rat. Horm Metab Res. 1982;14:479–482
  8. Murray FT, Cameron DF, Orth JM. Gonadal dysfunction in the spontaneously diabetic BB rat. Metabolism. 1983;32:141–147
  9. Seethalakshmi L, Menon M, Diamond D. The effect of streptozotocin-induced diabetes on the neuroendocrine-male reproductive tract axis of the adult rat. J Urol. 1987;138:190–194
  10. Murray FT, Orth J, Gunsalus G, Weisz J, Li JB, Jefferson LS, et al. The pituitary-testicular axis in the streptozotocin diabetic male rat: evidence for gonadotroph, Sertoli cell and Leydig cell dysfunction. Int J Androl. 1981;4:265–280
  11. Orth JM, Murray FT, Bardin CW. Ultrastructural changes in Leydig cells of streptozotocin-induced diabetic rats. Anat Rec. 1979;195:415–430
  12. Frenkel GP, Homonnai ZT, Drasnin N, Sofer A, Kaplan R, Kraicer PF. Fertility of the streptozotocin-diabetic male rat. Andrologia. 1978;10:127–136
  13. Bestetti G, Locatelli V, Tirone F, Rossi GL, Muller EE. One month of streptozotocin-diabetes induces different neuroendocrine and morphological alterations in the hypothalamo-pituitary axis of male and female rats. Endocrinology. 1985;117:208–216
  14. Cameron DF, Murray FT, Drylie DD. Interstitial compartment pathology and spermatogenic disruption in testes from impotent diabetic men. Anat Rec. 1985;213:53–62
  15. Dinulovic D, Radonjic G. Diabetes mellitus/male infertility (review). Arch Androl. 1990;25:277–293
  16. Distiller LA, Sagel J, Morley JE, Seftel HC. Pituitary responsiveness to luteinizing hormone-releasing hormone in insulin-dependent diabetes mellitus. Diabetes. 1975;24:378–380
  17. Gluud C, Madsbad S, Krarup T, Bennett P. Plasma testosterone and androstenedione in insulin dependent patients at time of diagnosis and during the first year of insulin treatment. Acta Endocrinol. 1982;100:406–409
  18. Cohen HN, Paterson KR, Wallace AM, Beastall GH, Manderson WG, MacCuish AC. Dissociation of adrenarche and gonadarche in diabetes mellitus. Clin Endocrinol. 1984;20:717–724
  19. Padron RS, Dambay A, Suarez R, Mas J. Semen analyses in adolescent diabetic patients. Acta Diabetol Lat. 1984;21:115–121
  20. Faerman I, Vilar O, Rivarola MA, Rosner JM, Jadzinsky MN, Fox D, et al. Impotence and diabetes. Studies of androgenic function in diabetic impotent males. Diabetes. 1972;21:23–30
  21. Ellenberg M. Impotence in diabetes: the neurologic factor. Ann Intern Med. 1971;75:213–219
  22. Kolodny RC, Kahn CB, Goldstein HH, Barnett DM. Sexual dysfunction in diabetic men. Diabetes. 1974;23:306–309
  23. Zeidler A, Gelfand R, Draus J, Tauscher JK, Chopp RT. Circadian variation in plasma prolactin, gonadotropins, and testosterone in diabetic male patients with and without impotence. Fertil Steril. 1981;35:653–656
  24. Ficher M, Zuckerman M, Fishkin RE, Goldman A, Neeb M, Fink PJ, et al. Do endocrines play an etiological role in diabetic and nondiabetic sexual dysfunctions?. J Androl. 1984;5:8–16
  25. Garcia-Diez LC, Corrales Hernandez JJ, Hernandez-Diaz J, Pedraz MJ, Miralles JM. Semen characteristics and diabetes mellitus: significance of insulin in male infertility. Arch Androl. 1991;26:119–128
  26. Ando S, Rubens R, Rottiers R. Androgen plasma levels in male diabetics. J Endocrinol Invest. 1984;7:21–24
  27. Bishop MW. Ageing and reproduction in the male (review). J Reprod Fertil Suppl. 1970;12:65–87
  28. Vermeulen A, Verdonck L. Radioimmunoassay of 17beta-hydroxy-5alpha-androstan-3-one, 4-androstene-3,17-dione, dehydroepiandrosterone, 17-hydroxyprogesterone and progesterone and its application to the human male plasma. J Steroid Biochem. 1976;7:1–10
  29. Rubens R, Dhont M, Vermeulen A. Further studies on Leydig cell function in old age. J Clin Endocrinol Metab. 1974;39:40–45
  30. Tilton RG, Hoffmann PL, Kilo C, Williamson JR. Pericyte degeneration and basement membrane thickening in skeletal muscle capillaries of human diabetics. Diabetes. 1981;30:326–334
  31. Williamson JR, Kilo C. Capillary basement membranes in diabetes (review). Diabetes. 1983;32:96–100 (suppl 2)
  32. Suoranta H. Changes in the small blood vessels of the adult human testis in relation to age and to some pathological conditions. Virchows Arch [A]. 1971;352:165–181
  33. Vermeulen A, Rubens R, Verdonck L. Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab. 1972;34:730–735
  34. Francavilla S, Santiemma V, Francavilla F, De Martino C, Santucci R, Fabbrini A. Ultrastructural changes in the seminiferous tubule wall and intertubular blood vessels in human cryptorchidism. Arch Androl. 1979;2:21–30
  35. Povoa H, Rezende MT, Almeida PC, Coelho de Souza A, Sargentelli L. Immunoreactive insulin in human semen. Acta Biol Med Germanica. 1972;29:183–184
  36. Hicks JJ, Rojas L, Rosado A. Insulin regulation of spermatozoa metabolism. Endocrinology. 1973;92:833–839
  37. Paz G, Homonnai ZT, Ayalon D, Cordova T, Kraicer PF. Immunoreactive insulin in serum and seminal plasma of diabetic and nondiabetic men and its role in the regulation of spermatozoal activity. Fertil Steril. 1977;28:836–840
  38. Ali ST, Shaikh RN, Siddiqi NA, Siddiqi PQ. Semen analysis in insulin-dependent/non-insulin-dependent diabetic men with/without neuropathy. Arch Androl. 1993;30:47–54
  39. Lipshultz LI, McConnell J, Benson GS. Current concepts of the mechanisms of ejaculation. Normal and abnormal states. J Reprod Med. 1981;26:499–507
  40. Thomas AJ. Ejaculatory dysfunction. Fertil Steril. 1983;39:445–454
  41. Witt MA, Grantmyre JE. Ejaculatory failure (review). World J Urol. 1993;11:89–95
  42. Hosking DJ, Bennett T, Hampton JR. Diabetic autonomic neuropathy (review). Diabetes. 1978;27:1043–1055
  43. Ellenberg M, Weber H. Retrograde ejaculation in diabetic neuropathy. Ann Intern Med. 1966;65:1237–1246
  44. Greene LF, Kelalis PP. Retrograde ejaculation of semen due to diabetic neuropathy. J Urol. 1967;98:696–698
  45. Shrivastav P, Swann J, Jeremy JY, Thompson C, Shaw RW, Dandona P. Sperm function and structure and seminal plasma prostanoid concentrations in men with IDDM. Diabetes Care. 1989;12:742–744

PII: S0090-4295(96)00573-0

Urology
Volume 49, Issue 4 , Pages 508-513 , April 1997

Article Tools