Urology
Volume 77, Issue 1 , Pages 250.e7-250.e13 , January 2011

From a Molecular Biological Viewpoint, Does Endothelin Type A Receptor Antagonist Therapy Reduce Diabetes-induced Testicular Damage in Rats?

Presented at 24th European Association of Urology Congress in Stockholm, March 17-21, 2009, and selected as a best ‘andrology miscellaneous’ poster presentation.

  • Buket Kosova

      Affiliations

    • Department of Medical Biology, Ege University School of Medicine, Izmir, Turkey
  • ,
  • Vildan Bozok Çetintaş

      Affiliations

    • Department of Medical Biology, Ege University School of Medicine, Izmir, Turkey
  • ,
  • Altuğ Yavaşoğlu

      Affiliations

    • Department of Embryology and Histology, Ege University School of Medicine, Izmir, Turkey
  • ,
  • Barış Altay

      Affiliations

    • Department of Urology, Ege University School of Medicine, Izmir, Turkey
  • ,
  • Hüseyin Aktuğ

      Affiliations

    • Department of Embryology and Histology, Ege University School of Medicine, Izmir, Turkey
    • Corresponding Author InformationReprint requests: Hüseyin Aktuğ, M.D., Department of Embryology and Histology, Ege University School of Medicine, 35100 Bornova, Izmir, Turkey

Received 28 January 2010 ,Accepted 16 April 2010.

References 

  1. Boujbiha MA, Hamden K, Guermazi F, et al. Testicular toxicity in mercuric chloride treated rats: association with oxidative stress. Reprod Toxicol. 2009;28:81–89
  2. Cai L, Chen S, Evans T, et al. Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism. Urol Res. 2000;28:342–347
  3. Masuzawa K, Goto K, Jesmin S, et al. An endothelin type A receptor antagonist reverses upregulated VEGF and ICAM-1 levels in streptozotocin-induced diabetic rat retina. Curr Eye Res. 2006;31:79–89
  4. Zhang ZH, Jin X, Zhang XS, et al. Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey. Contraception. 2003;68:297–301
  5. Allan DJ, Harmon BV, Roberts SA. Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat. Cell Prolif. 1992;25:241–250
  6. Desagher S, Martinou JC. Mitochondria as the central control point of apoptosis. Trends Cell Biol. 2000;10:369–377
  7. Grootegoed JA, Siep M, Baarends WM. Molecular and cellular mechanisms in spermatogenesis. Baillieres Best Pract Res Clin Endocrinol Metab. 2000;14:331–343
  8. Rosselot C, Kierszenbaum AL, Rivkin E, et al. Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin beta (ADAM2). Dev Dyn. 2003;227:458–467
  9. Luk JM, Lee NP, Shum CK, et al. Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis. J Cell Physiol. 2006;209:755–766
  10. Battistini B, Berthiaume N, Kelland NF, et al. Profile of past and current clinical trials involving endothelin receptor antagonists: the novel sentan class of drug. Exp Biol Med Maywood. 2006;231:653–695
  11. Benigni A, Colosio V, Brena C, et al. Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes. Diabetes. 1998;47:450–456
  12. Jesmin S, Zaedi S, Yamaguchi N, et al. Effects of dual endothelin receptor antagonist on antiapoptotic marker Bcl-2 expression in streptozotocin-induced diabetic rats. Exp Biol Med Maywood. 2006;231:1034–1039
  13. Aitken RJ, Harkiss D, Buckingham D. Relationship between iron-catalysed lipid peroxidation potential and human sperm function. J Reprod Fertil. 1993;98:257–265
  14. Alvarez JG, Storey BT. Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation. Gamete Res. 1989;23:77–90
  15. Alvarez JG, Touchstone JC, Blasco L, et al. Spontaneous lipid peroxidation and production of hydrogen peroxide and superoxide in human spermatozoa (Superoxide dismutase as major enzyme protectant against oxygen toxicity). J Androl. 1987;8:338–348
  16. Elmarakby AA, Loomis ED, Pollock JS, et al. NADPH oxidase inhibition attenuates oxidative stress but not hypertension produced by chronic ET-1. Hypertension. 2005;45:283–287
  17. Kamata K, Kanie N, Matsumoto T, et al. Endothelin-1-induced impairment of endothelium-dependent relaxation in aortas isolated from controls and diabetic rats. J Cardiovasc Pharmacol. 2004;44(Suppl 1):S186–S190
  18. Laplante MA, Wu R, Moreau P, et al. Endothelin mediates superoxide production in angiotensin II-induced hypertension in rats. Free Radic Biol Med. 2005;38:589–596
  19. Li L, Fink GD, Watts SW, et al. Endothelin-1 increases vascular superoxide via endothelin(A)-NADPH oxidase pathway in low-renin hypertension. Circulation. 2003;107:1053–1058
  20. Pampfer S, Cordi S, Vanderheyden I, et al. Expression and role of Bcl-2 in rat blastocysts exposed to high d-glucose. Diabetes. 2001;50:143–149
  21. Bossy-Wetzel E, Newmeyer DD, Green DR. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J. 1998;17:37–49
  22. Datta R, Kojima H, Yoshida K, et al. Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis. J Biol Chem. 1997;272:20317–20320
  23. Emoto Y, Manome Y, Meinhardt G, et al. Proteolytic activation of protein kinase C delta by an ice-like protease in apoptotic cells. EMBO J. 1995;14:6148–6156
  24. Kluck RM, Martin SJ, Hoffman BM, et al. Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system. EMBO J. 1997;16:4639–4649
  25. Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997;91:479–489
  26. Nicholson DW, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature. 1995;376:37–43
  27. Tewari M, Quan LT, O'Rourke K, et al. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 1995;81:801–809
  28. Schlegel J, Peters I, Orrenius S, et al. CPP32/apopain is a key interleukin 1 beta converting enzyme-like protease involved in Fas-mediated apoptosis. J Biol Chem. 1996;271:1841–1844
  29. Liu X, Kim CN, Yang J, et al. Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell. 1996;86:147–157
  30. Duan H, Orth K, Chinnaiyan AM, et al. Dixit, ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B. J Biol Chem. 1996;271:720–72416

PII: S0090-4295(10)00647-3

doi: 10.1016/j.urology.2010.04.052

Urology
Volume 77, Issue 1 , Pages 250.e7-250.e13 , January 2011