Meta-Analysis of Association Between TP53 Arg72Pro Polymorphism and Bladder Cancer Risk
Received 20 April 2010; accepted 26 April 2010. published online 13 July 2010. Corrected Proof
Objectives
To perform a meta-analysis to explore a more robust estimate of the effect of the TP53 Arg72Pro polymorphism on bladder cancer risk. Studies investigating the association between TP53 Arg72Pro polymorphism and bladder cancer risk have reported conflicting results.
Methods
All eligible studies were searched in PubMed. The quality of the studies was evaluated according to a predefined scale. Crude odds ratios, with the 95% confidence intervals, were assessed for the association using fixed- and random-effects models.
Results
We identified 10 case-control studies involving 3549 subjects for the present meta-analysis. Overall, no evidence of an association was observed between the TP53 genotypes and bladder cancer susceptibility when all the studies were pooled into the meta-analysis. However, a significantly decreased risk of bladder cancer was associated with TP53 genotypes for Arg/Arg versus Pro/Pro (odds ratio 0.74, 95% confidence interval 0.55-0.99) and Arg/Arg plus Arg/Pro versus Pro/Pro (odds ratio 0.77, 95% confidence interval 0.59-1.00) in Asians. In contrast, no effect of this polymorphism on bladder cancer in whites, Africans, or other population was observed when only high-quality scored studies were considered.
Conclusions
The results of the present meta-analysis suggest that the TP53 Arg72 allele is a protective factor and that the Pro/Pro genotype might increase the susceptibility to bladder cancer in Asians. The conflicting findings among studies might have resulted from variations in the allele frequencies among the different races, as well as the methodologic quality of the studies.
aState Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China
bInstitute of Biomedical Science, Fudan University, Shanghai, China
Reprint requests: Long Yu, M.D., Ph.D., State Key Laboratory of Genetic Engineering, Fudan University, 220 Handan Road, Shanghai 200433 China
This study was supported by the National 973 program of China (grant 2004CB518605), National 863 project of China (grant 2006AA020501), National Key Sci-Tech Special Project of China (grant 2008ZX10002-020), Project of the Shanghai Municipal Science and Technology Commission (grant 03dz14086), and National Natural Science Foundation of China (grants 30024001 and 30771188).
ABSTRACT