Urology
Volume 76, Issue 1 , Pages 25-31 , July 2010

The Genetic and Phenotypic Basis of Infertility in Men With Pediatric Urologic Disorders

References 

  1. Palermo G, et al. Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet. 1992;340(8810):17–18
  2. Alukal JP, Lamb DJ. Intracytoplasmic sperm injection (ICSI)—what are the risks?. Urol Clin North Am. 2008;35(2):277–288ix-ix
  3. Kent-First MG, et al. Infertility in intracytoplasmic-sperm-injection-derived sons. Lancet. 1996;348(9023):332
  4. Claahsen-van der Grinten HL, et al. Testicular adrenal rest tumors in adult males with congenital adrenal hyperplasia: evaluation of pituitary-gonadal function before and after successful testis-sparing surgery in eight patients. J Clin Endocrinol Metab. 2007;92(2):612–615
  5. Stikkelbroeck NM, et al. High prevalence of testicular adrenal rest tumors, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2001;86(12):5721–5728
  6. Bonaccorsi AC, Adler I, Figueiredo JG. Male infertility due to congenital adrenal hyperplasia: testicular biopsy findings, hormonal evaluation, and therapeutic results in three patients. Fertil Steril. 1987;47(4):664–670
  7. Urban MD, Lee PA, Migeon CJ. Adult height and fertility in men with congenital virilizing adrenal hyperplasia. N Engl J Med. 1978;299(25):1392–1396
  8. Matzuk MM, Lamb DJ. The biology of infertility: research advances and clinical challenges. Nat Med. 2008;14(11):1197–1213
  9. Aiman J, et al. Androgen insensitivity as a cause of infertility in otherwise normal men. N Engl J Med. 1979;300(5):223–227
  10. Yong EL, et al. Pregnancy after hormonal correction of severe spermatogenic defect due to mutation in androgen receptor gene. Lancet. 1994;344(8925):826–827
  11. Diamond DA, et al. Relationship of varicocele grade and testicular hypotrophy to semen parameters in adolescents. J Urol. 2007;178(4 Pt. 2):1584–1588
  12. Paduch DA, Niedzielski J. Semen analysis in young men with varicocele: preliminary study. J Urol. 1996;156(2 Pt. 2):788–790
  13. Bertolla RP, et al. Sperm nuclear DNA fragmentation in adolescents with varicocele. Fertil Steril. 2006;85(3):625–628
  14. Cayan S, et al. The effect of microsurgical varicocelectomy on serum follicle stimulating hormone, testosterone and free testosterone levels in infertile men with varicocele. BJU Int. 1999;84(9):1046–1049
  15. Lenzi A, et al. Sperm parameters after early left varicocele treatment. Fertil Steril. 1998;69(2):347–349
  16. Kolettis PN, et al. Sperm retrieval and intracytoplasmic sperm injection in patients with prune-belly syndrome. Fertil Steril. 1999;72(5):948–949
  17. Zimmermann S, et al. Targeted disruption of the Insl3 gene causes bilateral cryptorchidism. Mol Endocrinol. 1999;13(5):681–691
  18. Miller KD, Coughlin MT, Lee PA. Fertility after unilateral cryptorchidism (Paternity, time to conception, pretreatment testicular location and size, hormone and sperm parameters). Horm Res. 2001;55(5):249–253
  19. Chilvers C, et al. Undescended testis: the effect of treatment on subsequent risk of subfertility and malignancy. J Pediatr Surg. 1986;21(8):691–696
  20. Cendron M, et al. Cryptorchidism, orchiopexy and infertility: a critical long-term retrospective analysis. J Urol. 1989;142(2 Pt. 2):559–562[Discussion:572]
  21. Raman JD, Schlegel PN. Testicular sperm extraction with intracytoplasmic sperm injection is successful for the treatment of nonobstructive azoospermia associated with cryptorchidism. J Urol. 2003;170(4 Pt. 1):1287–1290
  22. Du T, Zamore PD. microPrimer: the Biogenesis and function of microRNA. Development. 2005;132(21):4645–4652
  23. Zhang L, et al. Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A. 2008;105(19):7004–7009
  24. Carroll PR, et al. Endocrine and exocrine profiles of men with testicular tumors before orchiectomy. J Urol. 1987;137(3):420–423
  25. Foster RS, et al. The fertility of patients with clinical stage I testis cancer managed by nerve sparing retroperitoneal lymph node dissection. J Urol. 1994;152(4):1139–1142[Discussion:1142-1143]
  26. Nalesnik JG, et al. Fertility in men after treatment for stage 1 and 2A seminoma. Am J Clin Oncol. 2004;27(6):584–588
  27. Lampe H, et al. Fertility after chemotherapy for testicular germ cell cancers. J Clin Oncol. 1997;15(1):239–245
  28. Scher D, Choi BB. Pregnancy after testicular sperm extraction at the time of radical orchiectomy for cancer in a solitary testis [abstract]. J Urol. 1999;161(Suppl):353
  29. Damani MN, et al. Postchemotherapy ejaculatory azoospermia: fatherhood with sperm from testis tissue with intracytoplasmic sperm injection. J Clin Oncol. 2002;20(4):930–936
  30. Hakim LS, Lobel SM, Oates RD. The achievement of pregnancies using assisted reproductive technologies for male factor infertility after retroperitoneal lymph node dissection for testicular carcinoma. Fertil Steril. 1995;64(6):1141–1146
  31. Schmidt KL, et al. Assisted reproduction in male cancer survivors: fertility treatment and outcome in 67 couples. Hum Reprod. 2004;19(12):2806–2810
  32. Agarwal A, et al. Fertility after cancer: a prospective review of assisted reproductive outcome with banked semen specimens. Fertil Steril. 2004;81(2):342–348
  33. Robboy SJ, et al. Dysgenesis of testicular and streak gonads in the syndrome of mixed gonadal dysgenesis: perspective derived from a clinicopathologic analysis of twenty-one cases. Hum Pathol. 1982;13(8):700–716
  34. Avolio L, et al. The long-term outcome in men with exstrophy/epispadias: sexual function and social integration. J Urol. 1996;156(2 Pt. 2):822–825
  35. Woodhouse CR. Sexual function in boys born with exstrophy, myelomeningocele, and micropenis. Urology. 1998;52(1):3–11
  36. Sorensen KO. Hypospadias With Special Reference to Aetiology. Copenhagen: Munksgaard; 1953;
  37. Jugenburg I, Kipikasa A. Fertility in patients with hypospadias. Acta Chir. 1988;30(2):86–93
  38. Shibahara H, et al. Successful pregnancies in a case of retrograde ejaculation associated with tethered spinal cord syndrome. J Assist Reprod Genet. 2000;17(4):233–237
  39. Decter RM, et al. Reproductive understanding, sexual functioning and testosterone levels in men with spinal bifida. J Urol. 1997;157(4):1466–1468
  40. Preliminary Investigation of the Fertility Status of Post Pubertal Males With Myelodysplasia. In: In International Pediatric Nephrology Association Meeting. Jerusalem. 1992;
  41. Nguyen HT, Peters CA. The long-term complications of posterior urethral valves. BJU Int. 1999;83(Suppl 3):23–28
  42. Woodhouse CR, Reilly JM, Bahadur G. Sexual function and fertility in patients treated for posterior urethral valves. J Urol. 1989;142(2 Pt. 2):586–588[Discussion:603-605]
  43. Puri A, et al. Semen analysis in post-pubertal patients with posterior urethral valves: a pilot study. Pediatr Surg Int. 2002;18(2-3):140–141
  44. Wernig M, et al. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature. 2007;448(7151):318–324
  45. Guan K, et al. Pluripotency of spermatogonial stem cells from adult mouse testis. Nature. 2006;440(7088):1199–1203
  46. Coward K, Kubota H, Parrington J. In vivo gene transfer into testis and sperm: developments and future application. Arch Androl. 2007;53(4):187–197
  47. Kanatsu-Shinohara M, et al. Production of knockout mice by random or targeted mutagenesis in spermatogonial stem cells. Proc Natl Acad Sci U S A. 2006;103(21):8018–8023
  48. Nagano M, et al. Transgenic mice produced by retroviral transduction of male germ-line stem cells. Proc Natl Acad Sci U S A. 2001;98(23):13090–13095
  49. Delhanty JD, et al. Sex determination of preimplantation embryos. Lancet. 1994;343(8896):549
  50. Sakkas D, Gardner DK. Noninvasive methods to assess embryo quality. Curr Opin Obstet Gynecol. 2005;17(3):283–288

 This work was supported in part by an American Urological Association Foundation Research Scholars Grant to MHH and US National Institutes of Health grants P01 HD36289 and U54 HD07495 from the Eunice Shriver National Institute of Child Health and R01 DK078121 from the National Institute of Kidney and Digestive Diseases to DJL.

PII: S0090-4295(10)00346-8

doi: 10.1016/j.urology.2010.03.011

Urology
Volume 76, Issue 1 , Pages 25-31 , July 2010

Article Tools