The Genetic and Phenotypic Basis of Infertility in Men With Pediatric Urologic Disorders
published online 07 May 2010.
Male factor is a major component of infertility for many couples. The presence of congenital genitourinary anomalies in male partners can cause male infertility. We reviewed the state-of-the-art treatment and outcomes for male infertility caused by pediatric urologic disorders. Disorders were classified by whether they led to infertility through pre-testis, testicular, or post-testis effects. Despite the complexity of pediatric urologic disorders that can affect fertility, natural paternity and paternity through assisted reproductive technology are common. Given the significant recent advances in infertility treatments, paternity with many currently untreatable pediatric disorders is likely in the future.
Department of Urology, Stanford University School of Medicine, Stanford, CA; Department of Molecular Cell Biology, Baylor College of Medicine, Houston, TX; and The Turek Clinic, San Francisco, CA
Reprint requests: Michael H. Hsieh, M.D., Ph.D., Department of Urology, Stanford University School of Medicine, 300 Pasteur Drive, S-287, Stanford, CA 94305
This work was supported in part by an American Urological Association Foundation Research Scholars Grant to MHH and US National Institutes of Health grants P01 HD36289 and U54 HD07495 from the Eunice Shriver National Institute of Child Health and R01 DK078121 from the National Institute of Kidney and Digestive Diseases to DJL.
ABSTRACT