Urology
Volume 75, Issue 4 , Pages 755-761 , April 2010

XMRV Infection in Patients With Prostate Cancer: Novel Serologic Assay and Correlation With PCR and FISH

  • Rebecca S. Arnold

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • Atlanta Veterans Affairs Medical Center, Decatur, Georgia
    • ,
  • Natalia V. Makarova

      Affiliations

    • Yerkes National Primate Research Center, Emory Vaccine Center, Emory University, Atlanta, Georgia
    • ,
  • Adeboye O. Osunkoya

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • Atlanta Veterans Affairs Medical Center, Decatur, Georgia
    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Suganthi Suppiah

      Affiliations

    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Takara A. Scott

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Nicole A. Johnson

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Sushma M. Bhosle

      Affiliations

    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Dennis Liotta

      Affiliations

    • Department of Chemistry, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Eric Hunter

      Affiliations

    • Yerkes National Primate Research Center, Emory Vaccine Center, Emory University, Atlanta, Georgia
    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Fray F. Marshall

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Hinh Ly

      Affiliations

    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Ross J. Molinaro

      Affiliations

    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • Jerry L. Blackwell

      Affiliations

    • Yerkes National Primate Research Center, Emory Vaccine Center, Emory University, Atlanta, Georgia
    • Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Atlanta, Georgia
    • ,
  • John A. Petros

      Affiliations

    • Department of Urology, Emory University School of Medicine, Atlanta, Georgia
    • Atlanta Veterans Affairs Medical Center, Decatur, Georgia
    • Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia
    • Corresponding Author InformationReprint requests: John A. Petros, M.D., Department of Urology, Emory University School of Medicine, 1365 Clifton Road, Building B, Atlanta, GA 30322

References 

  1. Urisman A, Molinaro RJ, Fischer N, et al. Identification of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant. PLoS Pathog. 2006;2:e25;–e25
  2. Fischer N, Hellwinkel O, Schulz C, et al. Prevalence of human gammaretrovirus XMRV in sporadic prostate cancer. J Clin Virol. 2008;43:277–283
  3. Schlaberg R, Choe DJ, Brown KR, et al. XMRV is present in malignant prostatic epithelium and is associated with prostate cancer, especially high-grade tumors. Proc Natl Acad Sci USA. 2009;106:16351–16356
  4. Hohn O, Krause H, Barbarotto P, et al. Lack of evidence for xenotropic murine leukemia virus-related virus(XMRV) in German prostate cancer patients. Retrovirology. 2009;6:92;–92
  5. Hong S, Klein EA, Das Gupta J, et al. Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer. J Virol. 2009;83:6995–7003
  6. Montefiori DC, Metch B, McElrath MJ, et al. Demographic factors that influence the neutralizing antibody response in recipients of recombinant HIV-1 gp120 vaccines. J Infect Dis. 2004;190:1962–1969
  7. Platt EJ, Wehrly K, Kuhmann SE, et al. Effects of CCR5 and CD4 cell surface concentrations on infections by macrophagetropic isolates of human immunodeficiency virus type 1. J Virol. 1998;72:2855–2864
  8. Meng G, Wei X, Wu X, et al. Primary intestinal epithelial cells selectively transfer R5 HIV-1 to CCR5+ cells. Nat Med. 2002;8:150–156
  9. Wei X, Decker JM, Liu H, et al. Emergence of resistant human immunodeficiency virus type 1 in patients receiving fusion inhibitor (T-20) monotherapy. Antimicrob Agents Chemother. 2002;46:1896–1905
  10. Li B, Decker JM, Johnson RW, et al. Evidence for potent autologous neutralizing antibody titers and compact envelopes in early infection with subtype C human immunodeficiency virus type 1. J Virol. 2006;80:5211–5218
  11. Burkhart MD, D'Agostino P, Kayman SC, et al. Involvement of the C-terminal disulfide-bonded loop of murine leukemia virus SU protein in a postbinding step critical for viral entry. J Virol. 2005;79:7868–7876

 This work was supported in part by the Research Scholar Award to Hinh Ly by the American Cancer Society (grant RSG-06-162-01-GMC) and by the Emory Biomarker Service Center.

PII: S0090-4295(10)00117-2

doi: 10.1016/j.urology.2010.01.038

Urology
Volume 75, Issue 4 , Pages 755-761 , April 2010

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