Urology
Volume 76, Issue 2 , Pages 283-288 , August 2010

Technetium-99m-L,L-Ethylenedicysteine Is More Effective Than Technetium-99m Diethylenetriamine Penta-acetic Acid for Excluding Obstruction in Patients With Pyelocalicinal Dilation

  • Mariana C.L. Lima

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • Corresponding Author InformationReprint requests: Mariana C. L. Lima, M.D., Serviço de Medicina Nuclear Av. Zeferino Vaz, s/n, Caixa Postal 6142, Campinas/SP–Brazil, CEP 13081-970
    • ,
  • Marcelo Lopes de Lima

      Affiliations

    • Division of Urology, Department of Surgery, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Carlos F.V. Pepe

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Elba C.S.C. Etchebehere

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Allan O. Santos

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Bárbara J. Amorim

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Edwaldo E. Camargo

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Ubirajara Ferreira

      Affiliations

    • Division of Urology, Department of Surgery, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Paulo C.R. Palma

      Affiliations

    • Division of Urology, Department of Surgery, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
    • ,
  • Celso D. Ramos

      Affiliations

    • Division of Nuclear Medicine, Department of Radiology, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

Received 29 November 2009 ,Accepted 20 December 2009.

References 

  1. Liu Y, Ghesani NV, Skurnick JH, et al. The F + 0 protocol for diuretic renography results in fewer interrupted studies due to voiding than the F − 15 protocol. J Nucl Med. 2005;46:1317–1320
  2. Shahrokh H, Movahhed M, Zargar Shoshtari MA, et al. Ethylenedicysteine versus diethylenetriamine pentaacetic acid as the carrier of technetium Tc 99m in diuretic renography for patients with upper urinary tract obstruction. Urol J. 2006;3:97–102
  3. Kabasakal L. Technetium-99m ethylene dicysteine: a new renal tubular function agent. Eur J Nucl Med. 2000;27:351–357
  4. Verbruggen AM, Nosco DL, Van Nerom CG, et al. Technetium-99m-L,L-ethylenedicysteine: a renal imaging agent: part I (Labeling and evaluation in animals). J Nucl Med. 1992;33:551–557
  5. Stadalnik RC, Vogel JM, Jansholt AL, et al. Renal clearance and extraction parameters of ortho-iodohippurate (I-123) compared with OIH(I-131) and PAH. J Nucl Med. 1980;21:168–170
  6. Thakur ML, Chauser BM, Hudson RF. Letter: the preparation of iodine-123 labelled sodium ortho-iodo hippurate and its clearance by the rat kidneys. Int J Appl Radiat Isot. 1975;26:319–320
  7. Fritzberg AR, Kasina S, Eshima D, et al. Synthesis and biological evaluation of technetium-99m MAG3 as a hippuran replacement. J Nucl Med. 1986;27:111–116
  8. Brown SC. Nuclear medicine in the clinical diagnosis and treatment of obstructive uropathy. In:  Ell PJ,  Gambhir SS editor. Nuclear Medicine in Clinical Diagnosis and Treatment. New York, NY: Churchill Livingstone; 2004;p. 1581–1602
  9. Taylor A, Eshima D, Christian PE, et al. Evaluation of Tc-99m mercaptoacetyltriglycine in patients with impaired renal function. Radiology. 1987;162:365–370
  10. Prenen JA, de Klerk JM, van het Schip AD, et al. Technetium-99m-MAG3 versus iodine-123-OIH: renal clearance and distribution volume as measured by a constant infusion technique. J Nucl Med. 1991;32:2057–2060
  11. Blaufox MD. Overview of renal nuclear medicine. In:  Ell PJ,  Gambhir SS editor. Nuclear Medicine in Clinical Diagnosis and Treatment. New York, NY: Churchill Livingstone; 2004;p. 1497–1499
  12. Domingues FC, Fujikawa GY, Decker H, et al. Comparison of relative renal function measured with either 99mTc-DTPA or 99mTc-EC dynamic scintigraphies with that measured with 99mTc-DMSA static scintigraphy. Int Braz J Urol. 2006;32:405–409
  13. Ozker K, Onsel C, Kabasakal L, et al. Technetium-99m-N,N ethylenedicysteine—a comparative study of renal scintigraphy with technetium-99m-MAG3 and iodine-131-OIH in patients with obstructive renal disease. J Nucl Med. 1994;35:840–845
  14. Mandell GA, Cooper JA, Leonard JC, et al. Procedure guideline for diuretic renography in children (Society of Nuclear Medicine). J Nucl Med. 1997;38:1647–1650
  15. Conway JJ, Maizels M. The “well tempered” diuretic renogram: a standard method to examine the asymptomatic neonate with hydronephrosis or hydroureteronephrosis (A report from combined meetings of the Society for Fetal Urology and members of the Pediatric Nuclear Medicine Council—the Society of Nuclear Medicine). J Nucl Med. 1992;33:2047–2051
  16. Fine EJ. Interventions in renal scintirenography. Semin Nucl Med. 1999;29:128–145
  17. Roarke MC, Sandler CM. Provocative imaging (Diuretic renography). Urol Clin North Am. 1998;25:227–249
  18. Abramson SJ, Papanicolaou N, Treves S, et al. Diuretic renography in the assessment of urinary tract dilatation in children. Pediatr Radiol. 1983;13:319–323
  19. Van Nerom CG, Bormans GM, De Roo MJ, et al. First experience in healthy volunteers with technetium-99m L,L-ethylenedicysteine, a new renal imaging agent. Eur J Nucl Med. 1993;20:738–746
  20. Gupta NK, Bomanji JB, Waddington W, et al. Technetium-99m-L,L-ethylenedicysteine scintigraphy in patients with renal disorders. Eur J Nucl Med. 1995;22:617–624
  21. Kabasakal L, Turoglu HT, Onsel C, et al. Clinical comparison of technetium-99m-EC, technetium-99m-MAG3 and iodine-131-OIH in renal disorders. J Nucl Med. 1995;36:224–228
  22. Kabasakal L, Atay S, Vural VA, et al. Evaluation of technetium-99m-ethylenedicysteine in renal disorders and determination of extraction ratio. J Nucl Med. 1995;36:1398–1403
  23. Stoffel M, Jamar F, Van Nerom C, et al. Evaluation of technetium-99m-L,L-EC in renal transplant recipients: a comparative study with technetium-99m-MAG3 and iodine-125-OIH. J Nucl Med. 1994;35:1951–1958
  24. Taylor A, Hansen L, Eshima D, et al. Comparison of technetium-99m-ll-EC isomers in rats and humans. J Nucl Med. 1997;38:821–826
  25. Kabasakal L, Halac M, Yapar AF, et al. Prospective validation of single plasma sample 99mTc-ethylenedicysteine clearance in adults. J Nucl Med. 1999;40:429–431
  26. Ugur O, Serdengecti M, Karacalioglu O, et al. Comparison of Tc-99m EC and Tc-99m DTPA captopril scintigraphy to diagnose renal artery stenosis. Clin Nucl Med. 1999;24:553–560
  27. Prvulovich EM, Bomanji JB, Waddington WA, et al. Clinical evaluation of technetium-99m-L,L-ethylenedicysteine in patients with chronic renal failure. J Nucl Med. 1997;38:809–814
  28. Surma MJ, Wiewiora J, Liniecki J. Usefulness of 99Tcm-N,N′-ethylene-1-dicysteine complex for dynamic kidney investigations. Nucl Med Commun. 1994;15:628–635
  29. De Geeter F, Saelens E, Van Steelandt H, et al. Differential renal uptake of technetium-99m-DMSA and technetium-99m-DTPA. J Nucl Med. 1993;34:1217–1218
  30. Quinn RJ, Elder GJ. Poor technetium-99m-DMSA renal uptake with near normal technetium-99m-DTPA uptake caused by tubulointerstitial renal disease. J Nucl Med. 1991;32:2273–2274

PII: S0090-4295(09)03120-3

doi: 10.1016/j.urology.2009.12.032

Urology
Volume 76, Issue 2 , Pages 283-288 , August 2010

Article Tools

* Image Usage & Resolution