Urology
Volume 75, Issue 3 , Pages 520-525 , March 2010

Lack of Pharmacodynamic Interaction of Silodosin, a Highly Selective α1a-Adrenoceptor Antagonist, With the Phosphodiesterase-5 Inhibitors Sildenafil and Tadalafil in Healthy Men

  • Scott A. MacDiarmid

      Affiliations

    • Bladder Control and Pelvic Pain Center, Alliance Urology Specialists, Greensboro, North Carolina
    • ,
  • Lawrence A. Hill

      Affiliations

    • Clinic Research Department, Watson Laboratories, Inc., Salt Lake City, Utah
    • Corresponding Author InformationReprint requests: Lawrence A. Hill, Pharm.D., R.Ph., Clinical Research, Watson Laboratories, Inc., Research Park, 577 Chipeta Way, Salt Lake City, UT 84108
    • ,
  • Weining Volinn

      Affiliations

    • Clinic Research Department, Watson Laboratories, Inc., Salt Lake City, Utah
    • ,
  • Gary Hoel

      Affiliations

    • Clinic Research Department, Watson Laboratories, Inc., Salt Lake City, Utah

Received 31 July 2009 ,Accepted 23 October 2009.

References 

  1. Wei JT, Calhoun EA, Jacobsen SJ. Benign prostatic hyperplasia. In:  Litwin MS,  Saigal CS editor. Urologic Diseases in America. Bethesda, MD: National Kidney and Urologic Diseases Information Clearinghouse; 2007;http://kidney.niddk.nih.gov/statistics/uda/NIH publication: 07-5512:43–67. Available at: (updated February 2007). Accessed August 28, 2008
  2. Seftel AD, Rosen RC, Rosenberg MT, et al. Benign prostatic hyperplasia evaluation, treatment and association with sexual dysfunction: practice patterns according to physician specialty. Int J Clin Pract. 2008;62:614–622
  3. Cambio AJ, Evans CP. Outcomes and quality of life issues in the pharmacological management of benign prostatic hyperplasia (BPH). Ther Clin Risk Manag. 2007;3:181–196
  4. Schwinn DA, Roehrborn CG. Alpha1-adrenoceptor subtypes and lower urinary tract symptoms. Int J Urol. 2008;15:193–199
  5. Lepor H. The evolution of alpha-blockers for the treatment of benign prostatic hyperplasia. Rev Urol. 2006;8(suppl 4):S3–S9
  6. Kloner RA. Cardiovascular effects of the 3 phosphodiesterase-5 inhibitors approved for the treatment of erectile dysfunction. Circulation. 2004;110:3149–3155
  7. Reffelmann T, Kloner RA. Sexual function in hypertensive patients receiving treatment. Vasc Health Risk Manag. 2006;2:447–455
  8. Shibata K, Foglar R, Horie K, et al. KMD-3213, a novel, potent, alpha 1a-adrenoceptor-selective antagonist: characterization using recombinant human alpha 1-adrenoceptors and native tissues. Mol Pharmacol. 1995;48:250–258
  9. Yamada S, Okura T, Kimura R. In vivo demonstration of alpha(1A)-adrenoceptor subtype selectivity of KMD-3213 in rat tissues. J Pharmacol Exp Ther. 2001;296:160–167
  10. Yamagishi R, Akiyama K, Nakamura S, et al. Effect of KMD-3213, an alpha 1a-adrenoceptor-selective antagonist, on the contractions of rabbit prostate and rabbit and rat aorta. Eur J Pharmacol. 1996;315:73–79
  11. Murata S, Taniguchi T, Takahashi M, et al. Tissue selectivity of KMD-3213, an alpha(1)-adrenoreceptor antagonist, in human prostate and vasculature. J Urol. 2000;164:578–583
  12. Marks LS, Gittelman MC, Hill LA, et al. Rapid efficacy of the highly selective α1a-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies. J Urol. 2009;181:2634–2640
  13. Moore RA, Derry S, McQuay J. Indirect comparison of interventions using published randomized trials: systematic review of PDE-5 inhibitors for erectile dysfunction. BMC Urol. 2005;5:18
  14. Auerbach SM, Gittelman M, Mazzu A, et al. Simultaneous administration of vardenafil and tamsulosin does not induce clinically significant hypotension in patients with benign prostatic hyperplasia. Urology. 2004;64:998–1003
  15. Kloner RA, Jackson G, Emmick JT, et al. Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men. J Urol. 2004;172:1935–1940

PII: S0090-4295(09)02848-9

doi: 10.1016/j.urology.2009.10.042

Urology
Volume 75, Issue 3 , Pages 520-525 , March 2010

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