Assessment of Patient-Reported Outcome of Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia and Treated With Tamsulosin HCl in Korea

Chang, Hyuk Soo; Park, Choal Hee; Kim, Dae Kyung; Park, Jong Kwan; Hong, Sung Joon; Chung, Byung Ha; Lee, Jeong Gu; Kim, Choung-Soo; Lee, Kyu-Sung; Kim, Joon Chul

doi:10.1016/j.urology.2009.09.010

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Volume 75, Issue 5 , Pages 1156-1161, May 2010

Assessment of Patient-Reported Outcome of Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia and Treated With Tamsulosin HCl in Korea

Hyuk Soo Chang
- Department of Urology, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea
Choal Hee Park
- Department of Urology, Dongsan Hospital, Keimyung University School of Medicine, Daegu, Korea
- Reprint requests: Choal Hee Park, M.D., 194 Dongsan-dong, Jung-gu, Dongsan Hospital, Department of Urology, Daegu, Korea
Dae Kyung Kim
- Department of Urology, Eulji University Hospital, Daejeon, Korea
Jong Kwan Park
- Department of Urology, Chonbuk National University Medical School, Jeonju, Korea
Sung Joon Hong
- Department of Urology, Yonsei University College of Medicine, Seoul, Korea
Byung Ha Chung
- Department of Urology, Yonsei University College of Medicine, Seoul, Korea
Jeong Gu Lee
- Department of Urology, Korea University College of Medicine, Seoul, Korea
Choung-Soo Kim
- Department of Urology, University of Ulsan College of Medicine, Ulsan, Korea
Kyu-Sung Lee
- Department of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea
Joon Chul Kim
- Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea

Received 23 July 2009; accepted 5 September 2009. published online 16 November 2009.

Objectives

To evaluate the effect of tamsulosin 0.2 mg once daily in treatment of patients with benign prostatic hyperplasia (BPH) using the new subjective assessment of patient-reported outcomes and the lower urinary tract symptoms (LUTS) outcome score (LOS).

Methods

Of 370 patients from 9 urology outpatient clinics, 299 finished this study. Tamsulosin 0.2 mg once daily was administered orally in a nonblind design for a 12-week period. The primary endpoint of this study was to evaluate the effect of tamsulosin with new assessing parameters; the most bothersome symptoms, BPH K1-short form and LOS. The secondary endpoint was to evaluate the effect of tamsulosin with conventional parameters, International Prostate Symptom Score (IPSS), maximum flow rate (Q_max.), and postvoiding residual urine volume.

Results

A total of 189 (63.2%) of 299 patients responded that their most bothersome symptom had been improved at 12 weeks after study. All 9 items in BPH K1-short form showed statistically significant improvement (P <.05). Overall, 20 (6.7%) patients met criteria for cured, 246 (82.3%) for improved, and 33 (11.0%) for failed. Statistically significant improvements were observed in IPSS, Q_max., and postvoiding residual urine volume (P <.05).

Conclusions

Tamsulosin 0.2 mg once daily may be an effective treatment, subjectively and objectively in patients with BPH. To evaluate the effect of the treatment in patients with BPH, it may be more effective to use the subjective quality of life questionnaire and the subjective-objective data integrated LOS than the currently used IPSS and Q_max..