Urology
Volume 75, Issue 1 , Pages 118-124 , January 2010

A Critical Appraisal of the Value of Lymph Node Dissection at Nephroureterectomy for Upper Tract Urothelial Carcinoma

  • Giovanni Lughezzani

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
    • ,
  • Claudio Jeldres

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Hendrik Isbarn

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Martini-clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany
    • ,
  • Shahrokh F. Shariat

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Maxine Sun

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • ,
  • Daniel Pharand

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Hugues Widmer

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Philippe Arjane

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Markus Graefen

      Affiliations

    • Martini-clinic, Prostate Cancer Center Hamburg-Eppendorf, Hamburg, Germany
    • ,
  • Francesco Montorsi

      Affiliations

    • Department of Urology, Vita-Salute San Raffaele University, Milan, Italy
    • ,
  • Paul Perrotte

      Affiliations

    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • ,
  • Pierre I. Karakiewicz

      Affiliations

    • Cancer Prognosis and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada
    • Department of Urology, University of Montreal, Montreal, Quebec, Canada
    • Corresponding Author InformationReprint requests: Pierre I. Karakiewicz, M.D., F.R.C.S.C., Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center (CHUM), 1058 rue St-Denis, Montréal, Québec, Canada, H2X 3J4

Received 23 May 2009 ,Accepted 9 July 2009.

References 

  1. Oosterlinck W, Solsona E, van der Meijden AP, et al. EAU guidelines on diagnosis and treatment of upper urinary tract transitional cell carcinoma. Eur Urol. 2004;46:147–154
  2. Munoz JJ, Ellison LM. Upper tract urothelial neoplasms: incidence and survival during the last 2 decades. J Urol. 2000;164:1523–1525
  3. Zigeuner R, Pummer K. Urothelial carcinoma of the upper urinary tract: surgical approach and prognostic factors. Eur Urol. 2008;53:720–731
  4. Brausi MA, Gavioli M, De Luca G, et al. Retroperitoneal lymph node dissection (RPLD) in conjunction with nephroureterectomy in the treatment of infiltrative transitional cell carcinoma (TCC) of the upper urinary tract: impact on survival. Eur Urol. 2007;52:1414–1418
  5. Roscigno M, Shariat SF, Margulis V, et al. Impact of lymph node dissection on cancer specific survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy. J Urol. 2009;181:2482–2489
  6. Ries LAG, Melbert D, Krapcho M, et al. SEER cancer statistics review, 1975-2004, National Cancer Institute. Bethesda, MD. Based on November 2006 SEER data submission, posted to SEER website http://seer.cancer.gov/csr/1975-2004/Accessed: January 2007
  7. Komatsu H, Tanabe N, Kubodera S, et al. The role of lymphadenectomy in the treatment of transitional cell carcinoma of the upper urinary tract. J Urol. 1997;157:1622–1624
  8. Miyake H, Hara I, Gohji K, et al. The significance of lymphadenectomy in transitional cell carcinoma of the upper urinary tract. Br J Urol. 1998;82:494–498
  9. Kondo T, Nakazawa H, Ito F, et al. Impact of the extent of regional lymphadenectomy on the survival of patients with urothelial carcinoma of the upper urinary tract. J Urol. 2007;178:1212–1217discussion: 1217
  10. Secin FP, Koppie TM, Salamanca JI, et al. Evaluation of regional lymph node dissection in patients with upper urinary tract urothelial cancer. Int J Urol. 2007;14:26–32
  11. Roscigno M, Cozzarini C, Bertini R, et al. Prognostic value of lymph node dissection in patients with muscle-invasive transitional cell carcinoma of the upper urinary tract. Eur Urol. 2008;53:794–802
  12. Donohue JP, Zachary JM, Maynard BR. Distribution of nodal metastases in nonseminomatous testis cancer. J Urol. 1982;128:315–320
  13. Vazina A, Dugi D, Shariat SF, et al. Stage specific lymph node metastasis mapping in radical cystectomy specimens. J Urol. 2004;171:1830–1834
  14. Bochner BH, Cho D, Herr HW, et al. Prospectively packaged lymph node dissections with radical cystectomy: evaluation of node count variability and node mapping. J Urol. 2004;172:1286–1290
  15. Stein JP, Penson DF, Cai J, et al. Radical cystectomy with extended lymphadenectomy: evaluating separate package versus en bloc submission for node positive bladder cancer. J Urol. 2007;177:876–881discussion: 881-882
  16. Weingartner K, Ramaswamy A, Bittinger A, et al. Anatomical basis for pelvic lymphadenectomy in prostate cancer: results of an autopsy study and implications for the clinic. J Urol. 1996;156:1969–1971
  17. Heidenreich A, Varga Z, Von Knobloch R. Extended pelvic lymphadenectomy in patients undergoing radical prostatectomy: high incidence of lymph node metastasis. J Urol. 2002;167:1681–1686
  18. Kondo T, Nakazawa H, Ito F, et al. Primary site and incidence of lymph node metastases in urothelial carcinoma of upper urinary tract. Urology. 2007;69:265–269

 Dr. Pierre I. Karakiewicz is partially supported by the University of Montreal Urology Associates, Fonds de la Recherche en Santé du Québec, the University of Montreal Department of Surgery and the University of Montreal Foundation.

PII: S0090-4295(09)02419-4

doi: 10.1016/j.urology.2009.07.1296

Urology
Volume 75, Issue 1 , Pages 118-124 , January 2010

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