Urology
Volume 75, Issue 4 , Pages 786-792 , April 2010

Expression and Localization of Hypoxia Proteins in Prostate Cancer: Prognostic Implications After Radical Prostatectomy

  • Judith Jans

      Affiliations

    • Department of Urology, University Medical Center Utrecht, The Netherlands
    • Laboratory of Experimental Oncology, University Medical Center Utrecht, The Netherlands
    • Corresponding Author InformationReprint requests: Judith Jans, Ph.D., Department of Urology, University Medical Center, PO Box 85500, 3508 GA, Utrecht, The Netherlands
  • ,
  • Jessica H. van Dijk

      Affiliations

    • Department of Urology, University Medical Center Utrecht, The Netherlands
  • ,
  • Susanne van Schelven

      Affiliations

    • Department of Urology, University Medical Center Utrecht, The Netherlands
  • ,
  • Petra van der Groep

      Affiliations

    • Department of Pathology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands
  • ,
  • Sofie H. Willems

      Affiliations

    • Department of Urology, University Medical Center Utrecht, The Netherlands
  • ,
  • Trudy N. Jonges

      Affiliations

    • Department of Pathology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands
  • ,
  • Paul J. van Diest

      Affiliations

    • Department of Pathology, University Medical Center Utrecht Cancer Center, Utrecht, The Netherlands
  • ,
  • J.L.H. Ruud Bosch

      Affiliations

    • Department of Urology, University Medical Center Utrecht, The Netherlands

Received 11 February 2009 ,Accepted 6 August 2009.

References 

  1. American Cancer Society. Global cancer facts and figures 2007. 2007;
  2. Thompson IM, Ankerst DP, Chi C, et al. Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial. J Natl Cancer Inst. 2006;98(8):529–534
  3. Brizel DM, Scully SP, Harrelson JM, et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 1996;56(5):941–943
  4. Hockel M, Schlenger K, Aral B, et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56(19):4509–4515
  5. Brahimi-Horn MC, Chiche J, Pouyssegur J. Hypoxia and cancer. J Mol Med. 2007;85(12):1301–1307
  6. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 1996;86(3):353–364
  7. Wang GL, Jiang BH, Rue EA, et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A. 1995;92(12):5510–5514
  8. Kallio PJ, Pongratz I, Gradin K, et al. Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the ARNT transcription factor. Proc Natl Acad Sci U S A. 1997;94(11):5667–5672
  9. Zhong H, Semenza GL, Simons JW, et al. Upregulation of hypoxia-inducible factor 1alpha is an early event in prostate carcinogenesis. Cancer Detect Prev. 2004;28(2):88–93
  10. Lee JW, Bae SH, Jeong JW, et al. Hypoxia-inducible factor (HIF-1) alpha: its protein stability and biological functions. Exp Mol Med. 2004;36(1):1–12
  11. Metzen E, Berchner-Pfannschmidt U, Stengel P, et al. Intracellular localisation of human HIF-1alpha hydroxylases: implications for oxygen sensing. J Cell Sci. 2003;116(7):1319–1326
  12. van den Ouden D, Hop WC, Kranse R, et al. Tumour control according to pathological variables in patients treated by radical prostatectomy for clinically localized carcinoma of the prostate. Br J Urol. 1997;79(2):203–211
  13. Endrizzi J, Seay T. The relationship between early biochemical failure and perineural invasion in pathological T2 prostate cancer. BJU Int. 2000;85(6):696–698
  14. Pound CR, Partin AW, Epstein JI, et al. Prostate-specific antigen after anatomic radical retropubic prostatectomy (Patterns of recurrence and cancer control). Urol Clin North Am. 1997;24(2):395–406
  15. Zincke H, Oesterling JE, Blute ML, et al. Long-term (15 years) results after radical prostatectomy for clinically localized (stage T2c or lower) prostate cancer. J Urol. 1994;152(5 Pt 2):1850–1857
  16. Catalona WJ, Smith DS. 5-year tumor recurrence rates after anatomical radical retropubic prostatectomy for prostate cancer. J Urol. 1994;152(5 Pt 2):1837–1842
  17. Trastour C, Benizri E, Ettore F, et al. HIF-1alpha and CA IX staining in invasive breast carcinomas: prognosis and treatment outcome. Int J Cancer. 2007;120(7):1451–1458
  18. Dellas K, Bache M, Pigorsch SU, et al. Prognostic impact of HIF-1alpha expression in patients with definitive radiotherapy for cervical cancer. Strahlenther Onkol. 2008;184(3):169–174
  19. Enatsu S, Iwasaki A, Shirakusa T, et al. Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung. Eur J Cardio Thorac Surg. 2006;29(6):891–895
  20. Lidgren A, Hedberg Y, Grankvist K, et al. Hypoxia-inducible factor 1alpha expression in renal cell carcinoma analyzed by tissue microarray. Eur Urol. 2006;50(6):1272–1277
  21. Vergis R, Corbishley CM, Norman AR, et al. Intrinsic markers of tumour hypoxia and angiogenesis in localised prostate cancer and outcome of radical treatment: a retrospective analysis of two randomised radiotherapy trials and one surgical cohort study. Lancet Oncol. 2008;9(4):342–351
  22. Boddy JL, Fox SB, Han C, et al. The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res. 2005;11(21):7658–7663
  23. Younes M, Brown RW, Stephenson M, et al. Overexpression of Glut1 and Glut3 in stage I nonsmall cell lung carcinoma is associated with poor survival. Cancer. 1997;80(6):1046–1051
  24. Haber RS, Rathan A, Weiser KR, et al. GLUT1 glucose transporter expression in colorectal carcinoma: a marker for poor prognosis. Cancer. 1998;83(1):34–40
  25. Cantuaria G, Fagotti A, Ferrandina G, et al. GLUT-1 expression in ovarian carcinoma: association with survival and response to chemotherapy. Cancer. 2001;92(5):1144–1150
  26. Chandler JD, Williams ED, Slavin JL, et al. Expression and localization of GLUT1 and GLUT12 in prostate carcinoma. Cancer. 2003;97(8):2035–2042
  27. Jokilehto T, Rantanen K, Luukkaa M, et al. Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness. Clin Cancer Res. 2006;12(4):1080–1087

PII: S0090-4295(09)02371-1

doi: 10.1016/j.urology.2009.08.024

Urology
Volume 75, Issue 4 , Pages 786-792 , April 2010