Urology
Volume 75, Issue 4 , Pages 799-804 , April 2010

Transabdominal Micro-ultrasound Imaging of Bladder Cancer in a Mouse Model: A Validation Study

  • Amit R. Patel

      Affiliations

    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio
    • Corresponding Author InformationReprint requests: Amit R. Patel, M.D., The Glickman Urological and Kidney Institute, The Cleveland Clinic, 9500 Euclid Ave, Q10-125, Cleveland, OH 44113
    • ,
  • Eddie S.Y. Chan

      Affiliations

    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio
    • ,
  • Donna E. Hansel

      Affiliations

    • Department of Anatomic Pathology, The Cleveland Clinic, Cleveland, Ohio
    • ,
  • C. Thomas Powell

      Affiliations

    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio
    • ,
  • Warren D. Heston

      Affiliations

    • Department of Cancer Biology, The Lerner Research Institute, The Cleveland Clinic, Cleveland, Ohio
    • ,
  • William A. Larchian

      Affiliations

    • Glickman Urological and Kidney Institute, The Cleveland Clinic, Cleveland, Ohio

Received 13 May 2009 ,Accepted 21 June 2009.

References 

  1. Jemal A, Siegel R, Ward E, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96
  2. Chan E, Patel A, Heston W, et al. Mouse orthotopic models for bladder cancer research. BJU Int, in press.
  3. Xiao Z, Hansen CB, Allen TM, et al. Distribution of photosensitizers in bladder cancer spheroids: implications for intravesical instillation of photosensitizers for photodynamic therapy of bladder cancer. J Pharm Pharm Sci. 2005;8:536–543
  4. Lyons SK. Advances in imaging mouse tumour models in vivo. J Pathol. 2005;205:194–205
  5. Chin JL, Kadhim SA, Batislam E, et al. Mycobacterium cell wall: an alternative to intravesical bacillus Calmette Guerin (BCG) therapy in orthotopic murine bladder cancer. J Urol. 1996;156:1189–1193
  6. Chin J, Kadhim S, Garcia B, et al. Magnetic resonance imaging for detecting and treatment monitoring of orthotopic murine bladder tumor implants. J Urol. 1991;145:1297–1301
  7. Kikuchi E, Xu S, Ohori M, et al. Detection and quantitative analysis of early stage orthotopic murine bladder tumor using in vivo magnetic resonance imaging. J Urol. 2003;170:1375–1378
  8. Jurczok A, Fornara P, Soling A. Bioluminescence imaging to monitor bladder cancer cell adhesion in vivo: a new approach to optimize a syngeneic, orthotopic, murine bladder cancer model. BJU Int. 2008;101:120–124
  9. Henriquez NV, van Overveld PG, Que I, et al. Advances in optical imaging and novel model systems for cancer metastasis research. Clin Exp Metastasis. 2007;24:699–705
  10. Hadaschik BA, Black PC, Sea JC, et al. A validated mouse model for orthotopic bladder cancer using transurethral tumour inoculation and bioluminescence imaging. BJU Int. 2007;100:1377–1384
  11. Satoh H, Morimoto Y, Arai T, et al. Intravesical ultrasonography for tumor staging in an orthotopically implanted rat model of bladder cancer. J Urol. 2007;177:1169–1173
  12. Goertz DE, Yu JL, Kerbel RS, et al. High-frequency Doppler ultrasound monitors the effects of antivascular therapy on tumor blood flow. Cancer Res. 2002;62:6371–6375
  13. Lyshchik A, Fleischer AC, Huamani J, et al. Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography. J Ultrasound Med. 2007;26:1575–1586

 This study was supported by Research Programs Committee, The Cleveland Clinic, RPC 2007–1004 and Flight Attendant Medical Research Institute, Clinical Innovator Award 072099.

PII: S0090-4295(09)00898-X

doi: 10.1016/j.urology.2009.06.047

Urology
Volume 75, Issue 4 , Pages 799-804 , April 2010

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