Urology
Volume 75, Issue 4 , Pages 985-991 , April 2010

Altered Expression of NDRG2 in the Testes of Experimental Rat Model of Cryptorchidism

  • Wugang Hou

      Affiliations

    • Department of Histology and Embryology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Wugang Hou, Jing Hu, and Yan Li contributed equally to this study.
    • ,
  • Jing Hu

      Affiliations

    • Department of Histology and Embryology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Wugang Hou, Jing Hu, and Yan Li contributed equally to this study.
    • ,
  • Yan Li

      Affiliations

    • Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Wugang Hou, Jing Hu, and Yan Li contributed equally to this study.
    • ,
  • Jie Zhao

      Affiliations

    • Department of Histology and Embryology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • ,
  • Zhen Li

      Affiliations

    • Department of Histology and Embryology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • ,
  • Xinping Liu

      Affiliations

    • Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • ,
  • Libo Yao

      Affiliations

    • Department of Biochemistry and Molecular Biology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • ,
  • Yuanqiang Zhang

      Affiliations

    • Department of Histology and Embryology, The Fourth Military Medical University, Xi'an, People's Republic of China
    • Corresponding Author InformationReprint requests: Yuanqiang Zhang, M.D., Department of Histology and Embryology, The Fourth Military Medical University, Xi'an 710032, People's Republic of China

Received 18 February 2009 ,Accepted 16 May 2009.

References 

  1. Rockett JC, Mapp FL, Garges JB, et al. Effects of hyperthermia on spermatogenesis, apoptosis, gene expression, and fertility in adult male mice. Biol Reprod. 2001;65:229–239
  2. Frankenhuis MT, Wensing CJ. Induction of spermatogenesis in the naturally cryptorchid pig. Fertil Steril. 1979;31:428–433
  3. Royere D, Guerif F, Laurent-Cadoret V, et al. Apoptosis in testicular germ cells. Int Congr S. 2004;1266:170–176
  4. Qu X, Zhai Y, Wei H, et al. Characterization and expression of 3 novel differentiation-related genes belong to the human NDRG gene family. Mol Cell Biochem. 2002;229:35–44
  5. Choi SC, Kim KD, Kim JT, et al. Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. FEBS Lett. 2003;553:413–418
  6. Wang LF, Liu N, Yao LB, et al. NDRG2 is a new HIF-1 target gene necessary for hypoxia-induced apoptosis in A549 cells. Cell Physiol Biochem. 2008;21:239–250
  7. Hu XL, Liu XP, Deng YC, et al. Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues. Cell Tissue Res. 2006;325:67–76
  8. Liu XP, Hu XL, Zhang J, et al. Preparation and application of monoclonal antibody against hNDRG2. Appl Biochem Biotechnol. 2009;152:306–315
  9. Moreno RD, Lizama C, Urzua N, et al. Caspase activation throughout the first wave of spermatogenesis in the rat. Cell Tissue Res. 2006;325:533–540
  10. Yin Y, Stahl BC, DeWolf WC, et al. p53 and Fas are sequential mechanisms of testicular germ cell apoptosis. J Androl. 2002;23:64–70
  11. Shikone T, Billiq H, Hsueh AJ. Experimentally induced cryptorchidism increases apoptosis in rat testis. Biol Reprod. 1994;51:865–872
  12. Johnson C, Jia Y, Wang C, et al. Role of caspase 2 in apoptotic signaling in primate and murine germ cells. Biol Reprod. 2008;79:806–814
  13. Zhao Y, Hou WG, Zhu HP, et al. Expression of thyrotropin-releasing hormone receptors in rat testis and their role in isolated Leydig's cells. Cell Tissue Res. 2008;334:283–294
  14. Tirado OM, Selva DM, Toran N, et al. Increased expression of estrogen receptor beta in pachytene spermatocytes after short-term methoxyacetic acid administration. J Androl. 2004;25:84–94
  15. Zhang ZH, Jin X, Zhang XS, et al. Bcl-2 and Bax are involved in experimental cryptorchidism-induced testicular germ cell apoptosis in rhesus monkey. Contraception. 2003;68:297–301
  16. Villumsen AL, Zachau-Christiansen B. Spontaneous alterations in position of the testis. Arch Dis Child. 1966;41:198–200
  17. Hadziselimovic F. Cryptorchidism, its impact on male fertility. Eur Urol. 2002;41:121–123
  18. Ellen TP, Ke Q, Zhang P, et al. NDRG1, a growth and cancer related gene: regulation of gene expression and function in normal and disease states. Carcinogenesis. 2008;29:2–8
  19. Lusis EA, Watson MA, Chicoine MR, et al. Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma. Cancer Res. 2005;65:7121–7126
  20. Yao L, Zhang J, Liu X. NDRG2: a Myc-repressed gene involved in cancer and cell stress. Acta Biochim Biophys Sin. 2008;40:625–635
  21. Liu N, Wang L, Li X, et al. N-Myc downstream-regulated gene 2 is involved in p53-mediated apoptosis. Nucleic Acids Res. 2008;36:5335–5349
  22. Otcu S, Karnak I, Kilinc A, et al. Orchidopexy or orchidectomy for preventing tissue hypoxia in contralateral testis following induction of ipsilateral abdominal testis associated with vas deferens obstruction. Urol Int. 2003;71:91–95
  23. Boulkroun S, Le Moellic C, Blot-Chabaud M, et al. Expression of androgen receptor and androgen regulation of NDRG2 in the rat renal collecting duct. Pflugers Arch. 2005;451:388–394
  24. Chaki SP, Misro MM, Ghosh D, et al. Apoptosis and cell removal in the cryptorchid rat testis. Apoptosis. 2005;10:395–405

 This study was supported by the Natural Science Foundation of China (2006: No. 30 600 340, 2007: No. 30 771 138, 2008: No. 30 871 309).

PII: S0090-4295(09)00689-X

doi: 10.1016/j.urology.2009.05.032

Urology
Volume 75, Issue 4 , Pages 985-991 , April 2010

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