Urology
Volume 75, Issue 4 , Pages 992-998 , April 2010

Increased Apoptosis of Spermatogenic Cells in Cryptorchidism Rat Model and Its Correlation With Transforming Growth Factor Beta Type II Receptor

  • Jian-Lin Yuan

      Affiliations

    • Department of Urology Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaan'xi, China
    • ,
  • Yun-Tao Zhang

      Affiliations

    • Department of Urology Surgery, Xijing Hospital, the Fourth Military Medical University, Xi'an, Shaan'xi, China
    • ,
  • Yong Wang

      Affiliations

    • Department of Urology Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaan'xi, China
    • Corresponding Author InformationReprint requests: Yong Wang, Ph.D., Department of Urology Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi'an, Shaan'xi, China 710032

Received 4 December 2008 ,Accepted 7 May 2009.

References 

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  2. Heninger NL, Staub C, Blanchard TL, et al. Germ cell apoptosis in the testes of normal stallions. Theriogenology. 2004;62:283–297
  3. Vigueras-Villaseñor RM, Molina-Ortiz D, et al. Effect of allopurinol on damage caused by free radicals to cryptorchid testes. Acta Histochem. 2009;111:127–137
  4. Konrad L, Keilani MM, Laible L, et al. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis. 2006;11:739–748
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  14. Zhang K, Shang Y, Liao S, et al. Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis. Biochem Biophys Res Commun. 2007;360:327–332
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  16. Barendrecht MM, Mulders AC, van der Poel H, et al. Role of transforming growth factor beta in rat bladder smooth muscle cell proliferation. J Pharmacol Exp Ther. 2007;322:117–122
  17. Konrad L, Keilani MM, Laible L, et al. Effects of TGF-betas and a specific antagonist on apoptosis of immature rat male germ cells in vitro. Apoptosis. 2006;11:739–748
  18. Olaso R, Pairault C, Boulogne B, et al. Transforming growth factor beta1 and beta2 reduce the number of gonocytes by increasing apoptosis. Endocrinology. 1998;139:733–740
  19. Itman C, Mendis S, Barakat B, et al. All in the family: TGF-beta family action in testis development. Reproduction. 2006;132:233–246
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 This Project was granted by the Natural Science Fund of Shaan'xi Province, China.

 Jian-Lin Yuan and Yun-Tao Zhang contributed equally to this research.

PII: S0090-4295(09)00642-6

doi: 10.1016/j.urology.2009.05.020

Urology
Volume 75, Issue 4 , Pages 992-998 , April 2010

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