Urology
Volume 74, Issue 5 , Pages 1004-1007 , November 2009

A HindIII Polymorphism of Fibronectin Gene Is Associated With Nephrolithiasis

  • Metin Onaran

      Affiliations

    • Department of Urology, School of Medicine, Gazi University, Ankara, Turkey
    • Corresponding Author InformationReprint requests: Metin Onaran, M.D., Department of Urology, School of Medicine, Gazi University, 06500 Besevler, Ankara, Turkey
    • ,
  • Akın Yılmaz

      Affiliations

    • Department of Medical Biology and Genetics, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • İlker Şen

      Affiliations

    • Department of Urology, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • Mehmet Ali Ergun

      Affiliations

    • Department of Medical Genetics, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • Ahmet Çamtosun

      Affiliations

    • Department of Urology, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • Bora Küpeli

      Affiliations

    • Department of Urology, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • Sevda Menevşe

      Affiliations

    • Department of Medical Biology and Genetics, School of Medicine, Gazi University, Ankara, Turkey
    • ,
  • İbrahim Bozkırlı

      Affiliations

    • Department of Urology, School of Medicine, Gazi University, Ankara, Turkey

Received 6 March 2009 ,Accepted 5 May 2009.

References 

  1. De Yoreo JJ, Qiu SR, Hoyer JR. Molecular modulation of calcium oxalate crystallization. Am J Physiol Renal Physiol. 2006;291:F1123–F1131
  2. Kumar V, Lieske JC. Protein regulation of intrarenal crystallization. Curr Opin Nephrol Hypertens. 2006;15:374–380
  3. Nakagawa Y, Ahmed M, Hall SL, et al. Isolation from human calcium oxalate renal stones of nephrocalcin, a glycoprotein inhibitor of calcium oxalate crystal growth (Evidence that nephrocalcin from patients with calcium oxalate nephrolithiasis is deficient in gamma-carboxyglutamic acid). J Clin Invest. 1987;79:1782–1787
  4. Kornblihtt AR, Pesce CG, Alonso CR, et al. The fibronectin gene as a model for splicing and transcription studies. FASEB J. 1996;10:248–257
  5. Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci. 2002;115:3861–3863
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  7. Avila JJ, Lympany PA, Pantelidis P, et al. Fibronectin gene polymorphisms associated with fibrosing alveolitis in systemic sclerosis. Am J Respir Cell Mol Biol. 1999;20:106–112
  8. Tsujihata M. Mechanism of calcium oxalate renal stone formation and renal tubular cell injury. Int J Urol. 2008;15:115–120
  9. Tsujihata M, Yoshimura K, Tsujikawa K, et al. Fibronectin inhibits endocytosis of calcium oxalate crystals by renal tubular cells. Int J Urol. 2006;13:743–746
  10. Koide T, Yoshioka T, Yamaguchi S, et al. Urinary crystal surface binding substances on calcium oxalate crystals. Urol Res. 1990;18:387–392
  11. Tsujihata M, Miyake O, Yoshimura K, et al. Fibronectin as a potent inhibitor of calcium oxalate urolithiasis. J Urol. 2000;164:1718–1723
  12. Tsujihata M, Miyake O, Yoshimura K, et al. Renal tubular cell injury and fibronectin. Urol Res. 2003;31:368–373
  13. Tsujihata M, Miyake O, Yoshimura K, et al. Comparison of fibronectin content in urinary macromolecules between normal subjects and recurrent stone formers. Eur Urol. 2001;40:458–462
  14. Miyake O, Kakimoto K, Tsujihata M, et al. Strong inhibition of crystal-cell attachment by pediatric urinary macromolecules: a close relationship with high urinary citrate secretion. Urology. 2001;58:493–497
  15. Nakata K, Ujike H, Sakai A, et al. Association study between the fibronectin gene and schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;116B:41–44
  16. Siemianowicz K, Gminski J, Francuz T, et al. Fibronectin gene polymorphism in patients with lung cancer. Oncol Rep. 2001;8:1289–1292
  17. Tsai FJ, Lin CC, Lu HF, et al. Urokinase gene 3′-UTR T/C polymorphism is associated with urolithiasis. Urology. 2002;59:458–461
  18. Seyhan S, Yavascaoglu I, Kilicarslan H, et al. Association of vitamin D receptor gene Taq I polymorphism with recurrent urolithiasis in children. Int J Urol. 2007;14:1060–1062
  19. Gao B, Yasui T, Okada A, et al. A polymorphism of the osteopontin gene is related to urinary calcium stones. J Urol. 2005;174:1472–1476
  20. Onaran M, Yılmaz A, Sen I, et al. Heparan sulfate gene polymorphism in calcium oxalate nephrolithiasis. Urol Res. 2009;37:47–50
  21. Miyazawa K, Aihara K, Ikeda R, et al. cDNA macroarray analysis of genes in renal epithelial cells exposed to calcium oxalate crystals. Urol Res. 2009;37:27–33

PII: S0090-4295(09)00631-1

doi: 10.1016/j.urology.2009.05.010

Urology
Volume 74, Issue 5 , Pages 1004-1007 , November 2009

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