Urology
Volume 74, Issue 1 , Pages 73-76 , July 2009

Effects of N-acetylcysteine on Semen Parameters and Oxidative/Antioxidant Status

  • Halil Ciftci

      Affiliations

    • Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey
    • Corresponding Author InformationReprint requests: Halil Ciftci, M.D., Department of Urology, Harran Üniversitesi School of Medicine, Tip Fakultesi Hastanesi, Sanliurfa TR-63100 Turkey
    • ,
  • Ayhan Verit

      Affiliations

    • Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey
    • ,
  • Murat Savas

      Affiliations

    • Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey
    • ,
  • Ercan Yeni

      Affiliations

    • Department of Urology, Harran University School of Medicine, Sanliurfa, Turkey
    • ,
  • Ozcan Erel

      Affiliations

    • Department of Clinical Biochemistry, Harran University School of Medicine, Sanliurfa, Turkey

Received 20 September 2008 ,Accepted 7 February 2009.

References 

  1. Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 2007;39:44–84
  2. McLachlan R, de Krester D. Male infertility: the case for continued research. Med J Aust. 2001;174:116–117
  3. Agarwal A, Prabakaran S, Allamaneni S. What an andrologist/urologist should know about free radicals and why. Urology. 2006;67:2–8
  4. Tremellen K. Oxidative stress and male infertility: a clinical perspective. Hum Reprod Update. 2008;14:243–258
  5. Said TM, Agarwal A, Sharma RK, et al. Impact of sperm morphology on DNA damage caused by oxidative stress induced by beta-nicotinamide adenine dinucleotide phosphate. Fertil Steril. 2005;83:95–103
  6. Agarwal A, Sharma RK, Nallella KP, et al. Reactive oxygen species as an independent marker of male factor infertility. Fertil Steril. 2006;86:878–885
  7. Oeda T, Henkel R, Ohmori H, et al. Scavenging effect of N-acetyl-l-cysteine against reactive oxygen species in human semen: a possible therapeutic modality for male factor infertility?. Andrologia. 1997;29:125–131
  8. Akiyama M. [In vivo scavenging effect of ethylcysteine on reactive oxygen species in human semen]. Nippon Hinyokika Gakkai Zasshi. 1999;90:421–428(in Japanese)
  9. Erkkilä K, Hirvonen V, Wuokko E, et al. N-acetyl-l-cysteine inhibits apoptosis in human male germ cells in vitro. J Clin Endocrinol Metab. 1998;83:2523–2531
  10. Griveau JF, Le Lannou D. Effects of antioxidants on human sperm preparation techniques. Int J Androl. 1994;17:225–231
  11. Arstall MA, Yang J, Stafford I. N-acetylcysteine in combination with nitroglycerine and streptokinase for the treatment of evolving acute myocardial infarction: safety and biochemical effects. Circulation. 1995;92:2855–2862
  12. Gogu SR, Agrawal KC. The protective role of zinc and N-acetylcysteine in modulating zidovudine induced hematopoietic toxicity. Life Sci. 1996;59:1323–1329
  13. Korinsky NL, Hartfield D, Horner H. Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue. Cancer Invest. 1996;14:202–210
  14. Lappas M, Permezel M, Rice GE. N-acetylcysteine inhibits phospholipid metabolism, proinflammatory cytokine release, protease activity, and nuclear factor kappa β deoxyribonucleic acid-binding activity in human fetal membrane in vitro. J Clin Endocrinol Metab. 2003;88:1723–1729
  15. Erel O. A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 2004;37:112–119
  16. Cao G, Prior RL. Comparison of different analytical methods for assessing total antioxidant capacity of human serum. Clin Chem. 1998;44:1309–1315
  17. Miyazawa T. Determination of phospholipid hydroperoxides in human blood plasma by a chemiluminescence-HPLC assay. Free Radic Biol Med. 1989;7:209–217
  18. Harma M, Harma M, Erel O. Increased oxidative stress in patients with hydatidiform mole. Swiss Med Wkly. 2003;133:563–566
  19. Aitken RJ, Buckingham D, Harris D. Use of a xanthine oxidase oxidant generating system to investigate the cytotoxic effects of reactive oxygen species on human spermatozoa. J Reprod Fertil. 1993;97:441–450
  20. Ventresca GP, Cicchetti V, Ferrari V. Drugs in Bronchial Mucology. In:  Braga PC,  Allegra L editor. Acetylcysteine. New York: Raven Publishing; 1989;p. 77–102
  21. Aruoma OI, Halliwell B, Hoey BM, et al. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med. 1989;6:593–597
  22. Gillissen A, Jaworska M, Orth M, et al. N-acystelyn, a novel lysine salt of N-acetylcysteine, to augment cellular antioxidant defense in vitro. Respir Med. 1997;91:159–168
  23. Threlkeld DS. Drug Facts and Comparisons. St Louis: Facts and Comparisons; 1997;1090-1094
  24. Tebenbein M. Hypersensitivity like reactions to N-acetylcysteine. Vet Hum Toxicol. 1984;26:S3–S5
  25. Elzanaty S, Malm J, Giwercman A. Visco-elasticity of seminal fluid in relation to the epididymal and accessory sex gland function and its impact on sperm motility. Int J Androl. 2004;27:94–100
  26. Siciliano L, Tarantino P, Longobardi F, et al. Impaired seminal antioxidant capacity in human semen with hyperviscosity oligoasthenozoospermia. J Androl. 2001;22:798–803
  27. Badawy A, Baker El Nashar A, El Totongy M. Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial. Fertil Steril. 2006;86:647–650

PII: S0090-4295(09)00301-X

doi: 10.1016/j.urology.2009.02.034

Urology
Volume 74, Issue 1 , Pages 73-76 , July 2009

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