Urology
Volume 73, Issue 3 , Pages 635-640 , March 2009

Hot Flashes During Androgen Deprivation Therapy With Luteinizing Hormone-Releasing Hormone Agonist Combined With Steroidal or Nonsteroidal Antiandrogen for Prostate Cancer

  • Hideki Sakai

      Affiliations

    • Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • Corresponding Author InformationReprint requests: Hideki Sakai, M.D., Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki 852-8501 Japan
    • ,
  • Tsukasa Igawa

      Affiliations

    • Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    • ,
  • Toshifumi Tsurusaki

      Affiliations

    • Division of Urology, Japanese Red Cross, Nagasaki Genbaku Hospital, Nagasaki, Japan
    • ,
  • Morishi Yura

      Affiliations

    • Division of Urology, Japanese Red Cross, Nagasaki Genbaku Hospital, Nagasaki, Japan
    • ,
  • Yasuyuki Kusaba

      Affiliations

    • Division of Urology, Japanese Red Cross, Nagasaki Genbaku Hospital, Nagasaki, Japan
    • ,
  • Mikio Hayashi

      Affiliations

    • Division of Urology, Nagasaki Medical Center, Omura, Japan
    • ,
  • Shotaro Iwasaki

      Affiliations

    • Division of Urology, Sasebo General Hospital, Sasebo, Japan
    • ,
  • Hironobu Hakariya

      Affiliations

    • Division of Urology, Ureshino Medical Center, Ureshino, Japan
    • ,
  • Tanetoshi Hara

      Affiliations

    • Division of Urology, Nagasaki Municipal Hospital, Nagasaki, Japan
    • ,
  • Hiroshi Kanetake

      Affiliations

    • Department of Nephro-Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan

Received 4 July 2008 ,Accepted 6 September 2008.

References 

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  2. Holzbeierlein JM, McLaughlin MD, Thrasher JB. Complications of androgen deprivation therapy for prostate cancer. Curr Opin Urol. 2004;14:177–183
  3. Thorpe SC, Azmatullah S, Fellows GJ, et al. A prospective, randomized study to compare goserelin acetate (Zoladex) versus cyproterone acetate (Cyprostat) versus a combination of the two in the treatment of metastatic prostatic carcinoma. Eur Urol. 1996;29:47–54
  4. Loprinzi CL, Michalak JC, Quella SK, et al. Megestrol acetate for the prevention of hot flashes. N Engl J Med. 1994;331:347–352
  5. Kotake T, Usami M, Akaza H, et al. Clinical evaluation of bicalutamide (Casodex) in patients with prostate cancer: A double-blind trial of bicalutamide versus chlormadinone acetate. Jpn J Urol Surg. 1996;9:243–256
  6. Hinotsu A, Niimi M, Akaza H, et al. Development of Japanese version of QOL questionnaire for bladder and prostate cancer patients using FACT-Bl and P: Pilot study. Gan To Kagaku Ryoho. 1999;26:657–666
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  8. Basaria S, Lieb J, Tang AM, et al. Long-term effects of androgen deprivation therapy in prostate cancer patients. Clin Endocrinol. 2002;56:779–786
  9. Charig CR, Rundle JS. Flashing: Long-term side effect of orchiectomy in treatment of prostatic carcinoma. Urology. 1989;33:175–178
  10. Carpenter JS, Andrykowski MA, Cordova M, et al. Hot flashes in postmenopausal women treated for breast carcinoma: Prevalence, severity, correlates, management, and relation to quality of life. Cancer. 1998;82:1682–1691
  11. Jonler M, Nielsen OS, Groenvold M, et al. Quality of life in patients with skeletal metastases of prostate cancer and status prior to start of endocrine therapy: Results from the Scandinavian Prostate Cancer Group study 5. Scand J Urol Nephrol. 2005;39:42–48
  12. Morrison J, Martin D, Blair R, et al. The use of medroxyprogesterone acetate for relief of climacteric symptoms. Am J Obstet Gynecol. 1980;138:99–104
  13. Schiff I, Tulchinsky D, Cramer D, et al. Oral medroxyprogesterone in the treatment of menopausal symptoms. JAMA. 1980;244:1443–1445
  14. Goodwin JW, Green SJ, Moinpour CM, et al. Phase III randomized placebo-controlled trial of two doses of megestrol acetate as treatment for menopausal symptoms in women with breast cancer: Southwest Oncology Group study 9626. J Clin Oncol. 2008;26:1650–1656
  15. Tsai CL, Matsumura K, Nakayama T. Effects of progesterone on thermosensitive neurons in preoptic slice preparations. Neurosci Lett. 1988;86:56–60
  16. Prostate Cancer Trialists' Collaborative Group. Maximum androgen blockade in advanced prostate cancer: An overview of the randomised trials. Lancet. 2000;355:1491–1498

PII: S0090-4295(08)01558-6

doi: 10.1016/j.urology.2008.09.013

Urology
Volume 73, Issue 3 , Pages 635-640 , March 2009

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