Urology
Volume 73, Issue 2 , Pages 225-231 , February 2009

Male Fertility After Cancer

  • Edmund S. Sabanegh Jr

      Affiliations

    • Corresponding Author InformationReprint requests: Edmund S. Sabanegh, Jr., M.D., Glickman Urological and Kidney Institute, Cleveland Clinic Foundation, 9500 Euclid Avenue, A100, Cleveland, OH
    • ,
  • Ahmed M. Ragheb

Received 30 June 2008 ,Accepted 7 August 2008.

References 

  1. Padron OF, Sharma RK, Thomas AJ, et al. Effects of cancer on spermatozoa quality after cryopreservation: A 12-year experience. Fertil Steril. 1997;67:326–331
  2. Schover LR, Brey K, Lichtin A, et al. Knowledge and experience regarding cancer, infertility, and sperm banking in younger male survivors. J Clin Oncol. 2002;20:1880–1889
  3. Wong WY, Thomas CM, Merkus JM, et al. Male factor subfertility: Possible causes and the impact of nutritional factors. Fertil Steril. 2000;73:435–442
  4. Costabile RA, Spevak M. Cancer and male factor infertility. Oncology (Williston Park). 1998;12:557–570
  5. Marmor D, Elefant E, Dauchez C, et al. Semen analysis in Hodgkin's disease before the onset of treatment. Cancer. 1986;57:1986–1987
  6. Bahadur G, Ling KL, Hart R, et al. Semen quality and cryopreservation in adolescent cancer patients. Hum Reprod. 2002;17:3157–3161
  7. American Cancer Society. Overview: Hodgkin's disease—How many men get Hodgkin disease?, 2008. Revised: 10/16/2007. Available from: http://www.cancer.org/docroot/CRI/content/CRI_2_2_1X_How_many_people_get_Hodgkins_disease_20.asp?sitearea=. Accessed June 2, 2008.
  8. Rueffer U, Breuer K, Josting A, et al. Male gonadal dysfunction in patients with Hodgkin's disease prior to treatment. Ann Oncol. 2001;12:1307–1311
  9. American Cancer Society. Overview: Testicular Cancer—How many men get testicular cancer?, 2008. Revised: 12/4/2007. Available from: http://www.cancer.org/docroot/CRI/content/CRI_2_2_1x_How_Many_People_Get_Testicular_Cancer_41.asp?sitearea=. Accessed June 2, 2008.
  10. Ho GT, Gardner H, DeWolf WC, et al. Influence of testicular carcinoma on ipsilateral spermatogenesis. J Urol. 1992;148:821–825
  11. Hutson JM, Hasthorpe S. Abnormalities of testicular descent. Cell Tissue Res. 2005;322:155–158
  12. Skakkebaek NE, Jørgensen N. Testicular dysgenesis and fertility. Andrologia. 2005;37:217–218
  13. Huyghe E, Matsuda T, Daudin M, et al. Fertility after testicular cancer treatments: Results of a large multicenter study. Cancer. 2004;100:732–737
  14. Petersen PM, Skakkebaek NE, Rørth M, et al. Semen quality and reproductive hormones before and after orchidectomy in men with testicular cancer. J Urol. 1999;161:822–826
  15. Shukla AR, Woodard C, Carr MC, et al. Experience with testis sparing surgery for testicular teratoma. J Urol. 2004;171:161–163
  16. Heidenreich A, Weissbach L, Höltl W, et al. Organ sparing surgery for malignant germ cell tumor of the testis. J Urol. 2001;166:2161–2165
  17. Paduch DA. Testicular cancer and male infertility. Curr Opin Urol. 2006;16:419–427
  18. Barrass BJ, Jones R, Graham JD, et al. Practical management issues in bilateral testicular cancer. BJU Int. 2004;93:1183–1187
  19. Petersen PM, Skakkebaek NE, Giwercman A. Gonadal function in men with testicular cancer. APMIS. 1998;106:24–36
  20. Ståhl O, Eberhard J, Jepson K, et al. Sperm DNA integrity in testicular cancer patients. Hum Reprod. 2006;21:3199–3205
  21. Shalet SM, Tsatsoulis A, Whitehead E, et al. Vulnerability of the human Leydig cell to radiation damage is dependent upon age. J Endocrinol. 1989;120:161–165
  22. Hansen PV, Trykker H, Svennekjaer IL, et al. Long term recovery of spermatogenesis after radiotherapy in patients with testicular cancer. Radiother Oncol. 1990;18:117–125
  23. Howell SJ, Shalet SM. Spermatogenesis after cancer treatment: Damage and recovery. J Natl Cancer Inst Monogr. 2005;34:12–17
  24. Nalesnik JG, Sabanegh ES, Eng TY, et al. Fertility in men after treatment for stage 1 and 2a seminoma. Am J Clin Oncol. 2004;27:584–588
  25. Apperley JF, Reddy N. Mechanism and management of treatment-related gonadal failure in recipients of high dose chemoradiotherapy. Blood Rev. 1995;9:93–116
  26. Bieri S, Rouzaud M, Miralbell R. Seminoma of the testis: Is scrotal shielding necessary when radiotherapy is limited to the paraaortic nodes. Radiother Oncol. 1999;50:349–353
  27. Mydlo JH, Lebed B. Does brachytherapy of the prostate affect sperm quality and/or fertility in younger men?. Scand J Urol Nephrol. 2004;38:221–224
  28. Khaksar SJ, Laing RW, Langley SE. Fertility after prostate brachytherapy. BJU Int. 2005;96:915
  29. Giwercman A, Petersen PM. Cancer and male infertility. Baillieres Best Pract Res Clin Endocrinol Metab. 2000;14:453–471
  30. Meistrich M. Potential genetic risks of using semen collected during chemotherapy. Hum Reprod. 1993;8:8–10
  31. Lee SJ, Schover LR, Partridge AH, et al. American Society of Clinical Oncology recommendations on fertility preservation in cancer patients. J Clin Oncol. 2006;24:2917–2931
  32. Pryzant RM, Meistrich ML, Wilson G, et al. Long term reduction in sperm count after chemotherapy with and without radiation therapy for non-Hodgkin's lymphomas. J Clin Oncol. 1993;11:239–247
  33. Whitehead E, Shalet SM, Blackledge G, et al. The effects of Hodgkin's disease and combination chemotherapy on gonadal function in the adult male. Cancer. 1982;49:418–422
  34. Fosså SD, Magelssen H. Fertility and reproduction after chemotherapy of adult cancer patients: Malignant lymphoma and testicular cancer. Ann Oncol. 2004;15(suppl 4):iv259–iv265
  35. Canellos GP, Anderson JR, Propert KJ, et al. Chemotherapy of advanced Hodgkin's disease with MOPP, ABVD or MOPP alternating with ABVD. N Engl J Med. 1992;327:1478–1484
  36. van der Kaaij MA, Heutte N, Le Stang N, et al. Gonadal function in males after chemotherapy for early stage Hodgkin's lymphoma treated in four subsequent trials by the European Organization for Research and Treatment of Cancer. J Clin Oncol. 2007;25:2825–2832
  37. Sieniawski M, Reineke T, Nogova L, et al. Fertility in male patients with advanced Hodgkin lymphoma treated with BEACOPP: A report of the German Hodgkin Study Group (GHSG). Blood. 2008;111:71–76
  38. Feldman DR, Bosl GJ, Sheinfeld J, et al. Medical treatment of advanced testicular cancer. JAMA. 2008;299:672–684
  39. Kollmannsberger C, Nichols C, Bokemeyer C. Recent advances in management of patients with platinum-refractory testicular germ cell tumors. Cancer. 2006;106:1217–1226
  40. Spermon JR, Ramos L, Wetzels AM, et al. Sperm integrity pre- and post-chemotherapy in men with testicular germ cell cancer. Hum Reprod. 2006;21:1781–1786
  41. Rivkees SA, Crawford JD. The relationship of gonadal activity and chemotherapy-induced gonadal damage. JAMA. 1988;259:2123–2125
  42. Meistrich ML, Wilson G, Huhtaniemi I. Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis. Cancer Res. 1999;59:3557–3560
  43. van Casteren NJ, van Santbrink EJ, van Inzen W, et al. Use rate and assisted reproduction technologies outcome of cryopreserved semen from 629 cancer patients. Fertil Steril. Epub 2008 Jan 11; doi:10.1016/j.fertnstert.2007.10.055.
  44. Wald M, Ross LS, Prins GS, et al. Analysis of outcomes of cryopreserved surgically retrieved sperm for IVF/ICSI. J Androl. 2006;27:60–65
  45. Schrader M, Müller M, Sofikitis N, et al. “Onco-tese”: Testicular sperm extraction in azoospermic cancer patients before chemotherapy—New guidelines?. Urology. 2003;61:421–425
  46. Keros V, Hultenby K, Borgström B, et al. Methods of cryopreservation of testicular tissue with viable spermatogonia in pre-pubertal boys undergoing gonadotoxic cancer treatment. Hum Reprod. 2007;22:1384–1395
  47. Wyns C, Curaba M, Martinez-Madrid B, et al. Spermatogonial survival after cryopreservation and short-term orthotopic immature human cryptorchid testicular tissue grafting to immunodeficient mice. Hum Reprod. 2007;22:1603–1611
  48. Aslam I, Fishel S, Moore H, et al. Fertility preservation of boys undergoing anticancer therapy: A review of the existing situation and prospects for the future. Hum Reprod. 2000;15:2154–2159
  49. Potts RJ, Newbury CJ, Smith G, et al. Sperm chromatin damage associated with male smoking. Mutat Res. 1999;423:103–111
  50. De Mas P, Daudin M, Vincent MC, et al. Increased aneuploidy in spermatozoa from testicular tumor patients after chemotherapy with cisplatin, etoposide and bleomycin. Hum Reprod. 2001;16:1204–1208
  51. Mottel N. Testicular cancer and male fertility. Prog Urol. 2000;10:193–199
  52. Meistrich ML, Byrne J. Genetic disease in offspring of long-term survivors of childhood and adolescent cancer treated with potentially mutagenic therapies. Am J Hum Genet. 2002;70:1069–1071

PII: S0090-4295(08)01504-5

doi: 10.1016/j.urology.2008.08.474

Urology
Volume 73, Issue 2 , Pages 225-231 , February 2009

Article Tools