Urology
Volume 72, Issue 2 , Pages 238-241, August 2008

Association of Prostate Cancer and Manganese Superoxide Dismutase AA Genotype Influenced by Presence of Occult Cancer in Control Group

  • Taro Iguchi

      Affiliations

    • Department of Urology, State University of New York Upstate Medical University, Syracuse, New York
    • Department of Urology, Osaka City University School of Medicine, Osaka, Japan
    • ,
  • Ching Y. Wang

      Affiliations

    • Department of Urology, State University of New York Upstate Medical University, Syracuse, New York
    • ,
  • Nicolas B. Delongchamps

      Affiliations

    • Department of Urology, State University of New York Upstate Medical University, Syracuse, New York
    • ,
  • Robert Sunheimer

      Affiliations

    • Department of Pathology, State University of New York Upstate Medical University, Syracuse, New York
    • ,
  • Tatsuya Nakatani

      Affiliations

    • Department of Urology, Osaka City University School of Medicine, Osaka, Japan
    • ,
  • Gustavo de la Roza

      Affiliations

    • Department of Pathology, State University of New York Upstate Medical University, Syracuse, New York
    • ,
  • Gabriel P. Haas

      Affiliations

    • Department of Urology, State University of New York Upstate Medical University, Syracuse, New York
    • Corresponding Author InformationReprint requests: Gabriel P. Haas, M.D., Department of Urology, State University of New York Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210.

Received 27 February 2008; accepted 12 March 2008. published online 25 June 2008.

Objectives

To investigate whether the inclusion of occult cancer in the control group can influence the association of prostate cancer and the polymorphism of manganese superoxide dismutase (MnSOD).

Methods

Prostate specimens and sera were obtained from 194 deceased men who did not have a history of prostate cancer. Eighteen-core biopsy specimens and whole-mount sections were evaluated histologically. The MnSOD genotype of the specimens was determined by polymerase chain reaction restriction fragment length polymorphism analysis.

Results

Tumors were present in 57 of the prostates, and biopsy detected 33 (including 1 false-positive finding). It detected 17 (1 false-positive finding) and missed 14 tumors in the subgroup of 135 specimens with a prostatic-specific antigen <4 ng/mL. The MnSOD AA genotype was associated with prostate cancer found in the step-sectioned specimens vs the control group in whom the absence of occult prostate cancer had been verified. However, no association was found if the control group consisted of subjects with negative biopsy results from the overall group or the subgroup with a prostatic-specific antigen level of <4 ng/mL.

Conclusions

The MnSOD AA genotype was associated with prostate cancer in our study; however, contamination of occult prostate cancer in the control group reduced the power of analysis and might yield seemingly negative results. Epidemiologic studies should strive to include control groups with a verified absence of occult cancer.

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 This study was supported by the National Cancer Institute (grant CA097751 to G. P. Haas) and the National Institute on Aging (grant AG021389 to G. P. Haas).

PII: S0090-4295(08)00611-0

doi:10.1016/j.urology.2008.03.064

Urology
Volume 72, Issue 2 , Pages 238-241, August 2008

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