Urology
Volume 72, Issue 6 , Pages 1208-1211 , December 2008

Assessment of Biochemical Recurrence Rate in Patients With Pathologically Confirmed Insignificant Prostate Cancer

  • Umberto Capitanio

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, Vita-Salute San Raffaele, Milan, Italy
    • ,
  • Sasha Ahyai

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Markus Graefen

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Claudio Jeldres

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Shahrokh F. Shariat

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • ,
  • Andreas Erbersdobler

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Thorsten Schlomm

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Alexander Haese

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Thomas Steuber

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Hans Heinzer

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Paul Perrotte

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • François Péloquin

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Daniel Pharand

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Philippe Arjane

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Hartwig Huland

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Pierre I. Karakiewicz

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • Corresponding Author InformationReprint requests: Pierre I. Karakiewicz, M.D., Cancer Prognostics and Health Outcomes Unit and University of Montreal Health Center (CHUM), 1058 Rue St.-Denis, Montréal, QC H2X 3J4, Canada

Received 14 February 2008 ,Accepted 18 April 2008.

References 

  1. Epstein JI, Walsh PC, Carmichael M, et al. Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer. JAMA. 1994;271:368–374
  2. Bastian PJ, Mangold LA, Epstein JI, et al. Characteristics of insignificant clinical T1c prostate tumors (A contemporary analysis). Cancer. 2004;101:2001–2005
  3. Chun FK, Briganti A, Jeldres C, et al. Tumour volume and high grade tumour volume are the best predictors of pathologic stage and biochemical recurrence after radical prostatectomy. Eur J Cancer. 2007;43:536–543
  4. Chun FK, Graefen M, Zacharias M, et al. Anatomic radical retropubic prostatectomy-long-term recurrence-free survival rates for localized prostate cancer. World J Urol. 2006;24:273–280
  5. Zincke H, Bergstralh EJ, Blute ML, et al. Radical prostatectomy for clinically localized prostate cancer: long-term results of 1,143 patients from a single institution. J Clin Oncol. 1994;12:2254–2263
  6. Walsh PC, Partin AW, Epstein JI. Cancer control and quality of life following anatomical radical retropubic prostatectomy: results at 10 years. J Urol. 1994;152:1831–1836
  7. Jeldres C, Suardi N, Walz J, et al. Validation of the contemporary Epstein criteria for insignificant prostate cancer in European men. Eur Urol. In press.
  8. Samaratunga H, Yaxley J, Kerr K, et al. Significance of minute focus of adenocarcinoma on prostate needle biopsy. Urology. 2007;70:299–302
  9. Epstein JI, Sanderson H, Carter HB, et al. Utility of saturation biopsy to predict insignificant cancer at radical prostatectomy. Urology. 2005;66:356–360
  10. Anast JW, Andriole GL, Bismar TA, et al. Relating biopsy and clinical variables to radical prostatectomy findings: can insignificant and advanced prostate cancer be predicted in a screening population?. Urology. 2004;64:544–550
  11. Sengupta S, Blute ML, Bagniewski SM, et al. After radical retropubic prostatectomy “insignificant” prostate cancer has a risk of progression similar to low-risk “significant” cancer. BJU Int. 2008;101:170–174
  12. Gleason D. FatVACURG: histologic grading and staining of prostatic carcinoma. In:  Tannenbaum M editors. Urologic Pathology. Philadelphia: Lea & Febiger; 1977;p. 171–187
  13. Makarov DV, Trock BJ, Humphreys EB, et al. Updated nomogram to predict pathologic stage of prostate cancer given prostate-specific antigen level, clinical stage, and biopsy Gleason score (Partin tables) based on cases from 2000-2005. Urology. 2007;69:1095–1101
  14. Partin AW, Mangold LA, Lamm DM, et al. Contemporary update of prostate cancer staging nomograms (Partin tables) for the new millennium. Urology. 2001;58:843–848
  15. Heath EI, Kattan MW, Powell IJ, et al. The effect of race/ethnicity on the accuracy of the 2001 Partin tables for predicting pathologic stage of localized prostate cancer. Urology. 2008;71:151–155
  16. Greene FL The American Joint Committee on Cancer. Updating the strategies in cancer staging. Bull Am Coll Surg. 2002;87:13–15
  17. Gallina A, Jeldres C, Chun FK, et al. Prediction of pathological stage is inaccurate in men with PSA values above 20 ng/mL. Eur Urol. 2007;52:1374–1380
  18. Bostwick DG, Shan A, Qian J, et al. Independent origin of multiple foci of prostatic intraepithelial neoplasia: comparison with matched foci of prostate carcinoma. Cancer. 1998;83:1995–2002
  19. Arora R, Koch MO, Eble JN, et al. Heterogeneity of Gleason grade in multifocal adenocarcinoma of the prostate. Cancer. 2004;100:2362–2366
  20. Shekarriz B, Tiguert R, Upadhyay J, et al. Impact of location and multifocality of positive surgical margins on disease-free survival following radical prostatectomy: a comparison between African-American and white men. Urology. 2000;55:899–903
  21. Porter CR, Kodama K, Gibbons RP, et al. 25-year prostate cancer control and survival outcomes: a 40-year radical prostatectomy single institution series. J Urol. 2006;176:569–574

 P. I. Karakiewicz is partially supported by the University of Montreal Health Center Urology Associated, Fonds de la Recherche en Santè du Quebec, the University of Montreal Department of Surgery, and the University of Montreal Health Center Foundation.

PII: S0090-4295(08)00545-1

doi: 10.1016/j.urology.2008.04.053

Urology
Volume 72, Issue 6 , Pages 1208-1211 , December 2008

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