Urology
Volume 72, Issue 6 , Pages 1208-1211, December 2008

Assessment of Biochemical Recurrence Rate in Patients With Pathologically Confirmed Insignificant Prostate Cancer

  • Umberto Capitanio

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, Vita-Salute San Raffaele, Milan, Italy
    • ,
  • Sasha Ahyai

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Markus Graefen

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Claudio Jeldres

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Shahrokh F. Shariat

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • ,
  • Andreas Erbersdobler

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Thorsten Schlomm

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Alexander Haese

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Thomas Steuber

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Hans Heinzer

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Paul Perrotte

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • François Péloquin

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Daniel Pharand

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Philippe Arjane

      Affiliations

    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • ,
  • Hartwig Huland

      Affiliations

    • Department of Urology, University of Hamburg, Hamburg, Germany
    • ,
  • Pierre I. Karakiewicz

      Affiliations

    • Cancer Prognostics and Health Outcomes Unit, University of Montreal, Montreal, QC, Canada
    • Department of Urology, University of Montreal, Montreal, QC, Canada
    • Corresponding Author InformationReprint requests: Pierre I. Karakiewicz, M.D., Cancer Prognostics and Health Outcomes Unit and University of Montreal Health Center (CHUM), 1058 Rue St.-Denis, Montréal, QC H2X 3J4, Canada

Received 14 February 2008; accepted 18 April 2008. published online 11 August 2008.

Objectives

To examine the rate of biochemical recurrence (BCR) in patients with pathologically confirmed insignificant prostate cancer (PIPCa).

Methods

A total of 1358 patients underwent open retropubic radical prostatectomy at the University Medical Center Eppendorf in Hamburg, Germany, and their specimens were whole-mounted, step-sectioned, and subjected to computer-based three-dimensional reconstruction. We identified patients who fulfilled the Epstein criteria for definition of PIPCa (tumor volume ≤0.5 mL, Gleason score ≤6, organ-confined disease) and we compared the BCR-free rates between the PIPCa and non-PIPCa groups.

Results

Pathologically confirmed insignificant prostate cancer was found in 69 patients (5%). At 1, 2, 5, and 10 years, the BCR-free rate for PIPCa patients was 100% vs, respectively, 97%, 91%, 74%, and 38% for other patients (log–rank P <.0001).

Conclusions

In patients with PIPCa, radical prostatectomy results in perfect biochemical recurrence rates, which confirms the validity of the PIPCa definition.

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 P. I. Karakiewicz is partially supported by the University of Montreal Health Center Urology Associated, Fonds de la Recherche en Santè du Quebec, the University of Montreal Department of Surgery, and the University of Montreal Health Center Foundation.

PII: S0090-4295(08)00545-1

doi:10.1016/j.urology.2008.04.053

Urology
Volume 72, Issue 6 , Pages 1208-1211, December 2008

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