Urology
Volume 72, Issue 4 , Pages 749-754 , October 2008

Relationship Between Serum Prostate-Specific Antigen Levels and Components of Metabolic Syndrome in Healthy Men

  • June Hyun Han

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • ,
  • Nak Young Choi

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • ,
  • Seong Hak Bang

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • ,
  • Oh Jung Kwon

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • ,
  • Young Woo Jin

      Affiliations

    • Radiation Health Research Institute, Korea Hydro & Nuclear Power Company, Limited, Seoul, Korea
    • ,
  • Soon Chul Myung

      Affiliations

    • Department of Urology, Chung-Ang University Hospital, Seoul, Korea
    • ,
  • In Ho Chang

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • ,
  • Tae Hyoung Kim

      Affiliations

    • Department of Urology, Chung-Ang University Hospital, Seoul, Korea
    • ,
  • Seung Hyun Ahn

      Affiliations

    • Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, Seoul, Korea
    • Corresponding Author InformationReprint requests: Seung Hyun Ahn, M.D., Ph.D., Department of Urology, Korea Electric Power Corporation Medical Foundation, Hanil General Hospital, 388-1 Sangmun-dong, Dobong-gu, Seoul 132-703 Korea

Received 28 November 2007 ,Accepted 30 January 2008.

References 

  1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the third national health and nutrition examination survey. JAMA. 2002;287:356–359
  2. Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. adults. Diab Care. 2004;27:2444–2449
  3. Park HS, Oh SW, Cho SI, et al. The metabolic syndrome and associated lifestyle factors among south Korean adults. Int J Epidemiol. 2004;33:328–336
  4. Werny DM, Saraiya M, Gregg EW. Prostate-specific antigen values in diabetic and nondiabetic US men, 2001-2002. Am J Epidemiol. 2006;164:978–983
  5. Fukui M, Ose H, Kitagawa Y, et al. Relationship between low serum endogenous androgen concentrations and arterial stiffness in men with type 2 diabetes mellitus. Metabolism. 2007;56:1167–1173
  6. Mäkinen JI, Perheentupa A, Irjala K, et al. Endogenous testosterone and serum lipids in middle-aged men. Atherosclerosis. 2007;197:688–693
  7. Amatruda JM, Hochstein M, Hsu TH, et al. Hypothalamic and pituitary dysfunction in obese males. Int J Obes. 1982;6:183–189
  8. Laaksonen DE, Niskanen L, Punnonen K, et al. Sex hormones, inflammation and the metabolic syndrome: A population-based study. Eur J Endocrinol. 2003;149:601–608
  9. Laaksonen DE, Niskanen L, Punnonen K, et al. Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men. Diab Care. 2004;27:1036–1041
  10. Chang IH, Han JH, Ahn SH. Association of obesity with prostate specific antigen and prostate specific antigen velocity in healthy young men. J Urol. 2008;179:886–891
  11. Krotkiewski M. Role of muscle capillarization and morphology in the development of insulin resistance and metabolic syndrome. Presse Med. 1994;23:1353–1356
  12. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157–163
  13. Barqawi AB, Golden BK, O'Donnell C, et al. Observed effect of age and body mass index on total and complexed PSA: Analysis from a national screening program. Urology. 2005;65:708–712
  14. Ku JH, Kim ME, Lee NK, et al. Influence of age, anthropometry, and hepatic and renal function on serum prostate-specific antigen levels in healthy middle-age men. Urology. 2003;61:132–136
  15. Fowke JH, Signorello LB, Chang SS, et al. Effects of obesity and height on prostate-specific antigen (PSA) and percentage of free PSA levels among African-American and Caucasian men. Cancer. 2006;107:2361–2367
  16. Kristal AR, Chi C, Tangen CM, et al. Associations of demographic and lifestyle characteristics with prostate-specific antigen (PSA) concentration and rate of PSA increase. Cancer. 2006;106:320–328
  17. Werny DM, Thompson T, Saraiya M, et al. Obesity is negatively associated with prostate-specific antigen in U.S. men, 2001-2004. Cancer Epidemiol Biomarkers Prev. 2007;16:70–76
  18. Ochiai A, Fritsche HA, Babaian RJ. Influence of anthropometric measurements, age, and prostate volume on prostate-specific antigen levels in men with a low risk of prostate cancer. Urology. 2005;66:819–823
  19. Burke CW, Anderson DC. Sex-hormone-binding globulin is an oestrogen amplifier. Nature. 1972;240:38–40
  20. Pasquali R, Casimirri F, Cantobelli S, et al. Effect of obesity and body fat distribution on sex hormones and insulin in men. Metabolism. 1991;40:101–104
  21. Walker BR. Steroid metabolism in metabolic syndrome X. Best Pract Res Clin Endocrinol Metab. 2001;15:111–122
  22. Rask E, Olsson T, Soderberg S, et al. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab. 2001;86:1418–1421
  23. Vollmer RT, Humphrey PA. Tumor volume in prostate cancer and serum prostate-specific antigen: Analysis from a kinetic viewpoint. Am J Clin Pathol. 2003;119:80–89
  24. Banez LL, Hamilton RJ, Partin AW, et al. Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. JAMA. 2007;298:2275–2280
  25. Svartberg J, von Muhlen D, Mathiesen E, et al. Low testosterone levels are associated with carotid atherosclerosis in men. J Intern Med. 2006;259:576–582
  26. Muller M, van den Beld AW, Bots ML, et al. Endogenous sex hormones and progression of carotid atherosclerosis in elderly men. Circulation. 2004;109:2074–2079
  27. Zmuda JM, Cauley JA, Kriska A, et al. Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men: A 13-year follow-up of former multiple risk factor intervention trial participants. Am J Epidemiol. 1997;146:609–617
  28. Duell PB, Bierman EL. The relationship between sex hormones and high-density lipoprotein cholesterol levels in healthy adult men. Arch Intern Med. 1990;150:2317–2320
  29. Barrett-Connor E, Khaw KT, Yen SS. Endogenous sex hormone levels in older adult men with diabetes mellitus. Am J Epidemiol. 1990;132:895–901
  30. Stellato RK, Feldman HA, Hamdy O, et al. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: Prospective results from the Massachusetts Male Aging Study. Diab Care. 2000;23:490–494
  31. Dalkin BL, Ahmann FR, Kopp JB. Prostate specific antigen levels in men older than 50 years without clinical evidence of prostatic carcinoma. J Urol. 1993;150:1837–1839
  32. Babaian RJ, Miyashita H, Evans RB, et al. The distribution of prostate specific antigen in men without clinical or pathological evidence of prostate cancer: Relationship to gland volume and age. J Urol. 1992;147:837–840
  33. Collins GN, Lee RJ, McKelvie GB, et al. Relationship between prostate specific antigen, prostate volume and age in the benign prostate. Br J Urol. 1993;71:445–450

PII: S0090-4295(08)00469-X

doi: 10.1016/j.urology.2008.01.084

Urology
Volume 72, Issue 4 , Pages 749-754 , October 2008

Article Tools

* Image Usage & Resolution