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Urology
Volume 72, Issue 2
, Pages 247-254
, August 2008
Prostate Tissue Androgens: History and Current Clinical Relevance
References
- Tissue and serum levels of principal androgens in benign prostatic hyperplasia and prostate cancer. Steroids. 2007;72:375–380
- Effect of testosterone replacement therapy on prostate tissue in men with late-onset hypogonadism: a randomized controlled trial. JAMA. 2006;296:2351–2361
- The androgen axis in recurrent prostate cancer. Clin Cancer Res. 2004;10:440–448
- . Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960;39:1157–1175
- Prostate concentrations of endogenous androgens by radioimmunoassay. J Steroid Biochem. 1976;7:301–307
- . The intranuclear binding of testosterone and 5-alpha-androstan-17-beta-ol-3-one by rat prostate. J Biol Chem. 1968;243:5953–5960
- Steroid 5alpha-reductase deficiency in man: an inherited form of male pseudohermaphroditism. Science. 1974;186:1213–1215
- . Tissue content of dihydrotestosterone in human prostatic hyperplasia is not supranormal. J Clin Invest. 1983;72:1772–1777
- The effect of finasteride in men with benign prostatic hyperplasia. N Engl J Med. 1992;327:1185–1191
- The influence of finasteride on the development of prostate cancer. N Engl J Med. 2003;349:215–224
- Racial differences in prostate androgen levels in men with clinically localized prostate cancer. J Urol. 2004;171:2277–2280
- . Androgen concentration in blacks with benign and malignant prostatic disease. J Urol. 1988;140:160–164
- Prostatic tissue testosterone and dihydrotestosterone in African-American and white men. Urology. 2006;68:337–341
- . Dihydrotestosterone in prostatic hypertrophy (I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man). J Clin Invest. 1970;49:1737–1745
- Simultaneous determination of testosterone, dihydrotestosterone and 5 alpha-androstan-3 alpha,-17 beta-diol by isotopic dilution mass spectrometry in plasma and prostatic tissue of patients affected by benign prostatic hyperplasia: effects of 3-month treatment with a GnRH analog. J Androl. 1988;9:234–240
- Three-month treatment with a long-acting gonadotropin-releasing hormone agonist of patients with benign prostatic hyperplasia: effects on tissue androgen concentration, 5 alpha-reductase activity and androgen receptor content. J Clin Endocrinol Metab. 1989;68:461–468
- Finasteride, an inhibitor of 5 alpha-reductase, suppresses prostatic dihydrotestosterone in men with benign prostatic hyperplasia. J Clin Endocrinol Metab. 1992;74:505–508
- Changes in the endocrine environment of the human prostate transition zone with aging: simultaneous quantitative analysis of prostatic sex steroids and comparison with human prostatic histological composition. Prostate. 2000;42:45–55
- The effect of dutasteride on intraprostatic dihydrotestosterone concentrations in men with benign prostatic hyperplasia. Prostate Cancer Prostatic Dis. 2007;10:149–154
- Persistent intraprostatic androgen concentrations after medical castration in healthy men. J Clin Endocrinol Metab. 2006;91:3850–3856
- Comparison of androgen metabolites in benign prostatic hypertrophy (BPH) and normal prostate. J Clin Endocrinol Metab. 1976;43:686–688
- A comparative study of binding, metabolism and endogenous levels of androgens in normal, hyperplastic and carcinomatous human prostate. J Steroid Biochem. 1979;11:615–624
- . Benign prostatic hyperplasia: etiology, pathophysiology, epidemiology, and natural history. In: Wein AJ, Kavoussi LR, Novick AC, et al. editor. Campbell-Walsh Urology. vol XVI:Philadelphia: WB Saunders; 2007;p. 2727–2738
- Effect of the dual 5alpha-reductase inhibitor dutasteride on markers of tumor regression in prostate cancer. J Urol. 2004;172:915–919
- The effects of the dual 5alpha-reductase inhibitor dutasteride on localized prostate cancer—results from a 4-month pre-radical prostatectomy study. Prostate. 2006;66:1674–1685
- . Prevention of benign prostatic hyperplasia disease. J Urol. 2006;176:1299–1306
- Tissue effects of saw palmetto and finasteride: use of biopsy cores for in situ quantification of prostatic androgens. Urology. 2001;57:999–1005
- Dutasteride, the dual 5alpha-reductase inhibitor, inhibits androgen action and promotes cell death in the LNCaP prostate cancer cell line. Prostate. 2004;58:130–144
- The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostate. Urology. 2005;65:76–82
- Differential alterations in 5alpha-reductase type 1 and type 2 levels during development and progression of prostate cancer. Prostate. 2005;63:231–239
- Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trial. J Urol. 2004;172:1314–1317
- Comparison of prostatic cancer tissue dihydrotestosterone levels at the time of relapse following orchiectomy or estrogen therapy. J Urol. 1984;132:693–696
- . The influence of androgen deprivation therapy on dihydrotestosterone levels in the prostatic tissue of patients with prostate cancer. Clin Cancer Res. 2004;10:7121–7126
- The influence of reversible androgen deprivation on serum prostate-specific antigen levels in men with benign prostatic hyperplasia. J Urol. 1989;141:987–992
- Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer. Cancer Res. 2007;67:5033–5041
- Gene expression analysis of human prostate carcinoma during hormonal therapy identifies androgen-responsive genes and mechanisms of therapy resistance. Am J Pathol. 2004;164:217–227
- The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor. Cancer Res. 2004;64:765–771
- Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res. 2006;66:2815–2825
- Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer. Prostate Cancer Prostatic Dis. 2007;10:301–306
- . Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005;96:1241–1246
- Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer. Cancer Res. 2000;60:6630–6640
- . Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol. 2005;23:8253–8261
- . Risks of testosterone-replacement therapy and recommendations for monitoring. N Engl J Med. 2004;350:482–492
- . The response of metastatic adenocarcinoma of the prostate to exogenous testosterone. J Urol. 1981;126:372–375
- . Phosphorus-32 for intractable pain in carcinoma of prostate: analysis of androgen priming, parathormone rebound, and combination therapy. Urology. 1977;9:137–139
- Prostate cancer in men using testosterone supplementation. J Urol. 2005;174:534–538
- Dreifus C. A Conversation with Andrew von Eschenbach: Director Tries to Untangle Web of Cancer Controversies, Science Section. New York Times. March 11, 2003.
- Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan. J Androl. 2003;24:299–311
- . Testosterone and Aging: Clinical Research Directions. In: Washington, DC: National Academies Press; 2004;p. 219
- Dihydrotestosterone measured in core biopsies from prostatic tissues. Am J Clin Oncol. 1988;11(suppl 2):S27–S29
- Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization. Anal Bioanal Chem. 2005;382:1035–1043
- Analysis of testosterone and dihydrotestosterone from biological fluids as the oxime derivatives using high-performance liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21:3200–3206
- Sex steroids in the umbilical circulation of fetal rhesus monkeys from the time of gonadal differentiation. J Clin Endocrinol Metab. 1980;50:900–905
- A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate. J Androl. 2008;29:102–105
- Tissue selectivity of the anabolic steroid, 19-nor-4-androstenediol-3{beta},17{beta}-diol in male Sprague-Dawley rats: selective stimulation of muscle mass and bone mineral density relative to prostate mass. Endocrinology. 2007;Epub Dec 20
This work was supported by the Urological Sciences Research Foundation (L.S.M.); a Career Development Award from the Prostate Cancer Foundation, a Young Investigator Award from the American Society of Clinical Oncology, and National Institutes of Health grant K23 CA122820-02 (E.A.M.); and the National Institutes of Health/National Cancer Institute Pacific Northwest Prostate Cancer SPORE grant P50CA97186 (P.S.N.).
PII: S0090-4295(08)00372-5
doi: 10.1016/j.urology.2008.03.033
© 2008 Elsevier Inc. All rights reserved.
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Urology
Volume 72, Issue 2
, Pages 247-254
, August 2008
